*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : VO8640000
CHEMICAL NAME : Salinomycin, 4-methyl-, (4S)
CAS REGISTRY NUMBER : 55134-13-9
BEILSTEIN REFERENCE NO. : 1678311
LAST UPDATED : 199612
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C43-H72-O11
MOLECULAR WEIGHT : 765.15
WISWESSER LINE NOTATION : T6XOX DHJ DQ A-& BT6OXTJ C1 E1 FY2&VY1&YQY1&- BT6OTJ
C1 E1 FY2&VQ&& C-& BT5OXTJ E1 E- FT6OTJ
COMPOUND DESCRIPTOR : Drug
Natural Product
SYNONYMS/TRADE NAMES :
* A 28086A
* Antibiotic A 28086A
* Antibiotic A-28086 factor A
* Antibiotic C 7819B
* C 7819B
* Compound 79891
* 4-Methylsalinomycin
* Monteban
* Narasin
* Narasin A
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 18500 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,318,1994
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >400 mg/m3/30M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,318,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1960 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,318,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 15800 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,318,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 7 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca
Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,495,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >10 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,318,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 15500 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,318,1994
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 455 mg/kg/91D-I
TOXIC EFFECTS :
Behavioral - ataxia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,318,1994
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 873 mg/kg/91D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,318,1994
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 182 mg/kg/91D-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,318,1994
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 36500 ug/kg/1Y-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,318,1994
*** END OF RECORD ***