*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VP5010000
CHEMICAL NAME           : Sanguinaria canadensis L., alkaloid extract
SUBSTANCE DEFINITION :
   Contains 33% sanguinarine chloride and 68% total benzophenanthrine alkaloid
REFERENCE :
   JCLDED Journal of Clinical Dentistry.  (Professional Audience Communications
   Inc., P.O. Box 243, Yardley, PA 19067)  V.1-    1988-
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Bloodroot
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1440 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 5,176,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 29,199,1987
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 650 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   JCLDED Journal of Clinical Dentistry.  (Professional Audience Communications
   Inc., P.O. Box 243, Yardley, PA 19067)  V.1-    1988-
   Volume(issue)/page/year: 1(3),59,1989
 
                            *** END OF RECORD ***