*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : VQ1925000 CHEMICAL NAME : Saramycetin CAS REGISTRY NUMBER : 11130-70-4 LAST UPDATED : 199606 DATA ITEMS CITED : 5 COMPOUND DESCRIPTOR : Drug Natural Product SYNONYMS/TRADE NAMES : * NSC-100844 * Ro-2-7758 * X-5079C *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 650 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),411,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -,436,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 375 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,586,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature increase REFERENCE : NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,232,1966 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 28 mg/kg/14D-I TOXIC EFFECTS : Brain and Coverings - other degenerative changes Spinal Cord - other degenerative changes Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,232,1966 *** END OF RECORD ***