*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VS2900000
CHEMICAL NAME           : 9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol
CAS REGISTRY NUMBER     : 67-97-0
LAST UPDATED            : 199701
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C27-H44-O
MOLECULAR WEIGHT        : 384.71
WISWESSER LINE NOTATION : L56 FYTJ A1 BY1&3Y1&1 FU2U- BL6YYTJ AU1 DQ
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Arachitol
   * Calciol
   * Cholecalciferol
   * Cholecalciferol, D3
   * Colecalciferol
   * 7-Dehydrocholestrol, activated
   * Delsterol
   * Deparal
   * D3-Vigantol
   * Oleovitamin D3
   * Quintox
   * Ricketon
   * Rampage
   * Vigorsan
   * Trivitan
   * Vitamin D3
   * Vitinc dan-dee-3
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 39 mg/kg/34W-I
TOXIC EFFECTS :
   Behavioral - anorexia (human)
   Behavioral - irritability
   Gastrointestinal - decreased motility or constipation
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   295,1173,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   43,125,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 42500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de
   Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France)
   V.1-  1947-  Volume(issue)/page/year: 43(255-256),14,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 136 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VHTODE Veterinary and Human Toxicology.  (American College of Veterinary and
   Comparative Toxicology, Publication Office, Comparative Toxicology,
   Manhattan, KS 66506)  V.19-    1977-  Volume(issue)/page/year: 31,105,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - other changes
REFERENCE :
   JAVMA4 Journal of the American Veterinary Medical Association.  (American
   Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196)  V.48-
   1915-  Volume(issue)/page/year: 193,211,1988
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 90 mg/kg
SEX/DURATION            : female 12-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   FOMOAJ Folia Morphologica (Warsaw).  (Panstwowy Zaklad Wydawnictw
   Lekarskich, ul. Dluga 38-40, 00 238 Warsaw, Poland)  V.1-    1929-
   Volume(issue)/page/year: 29,333,1970

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80574
       No. of Facilities: 179 (estimated)
       No. of Industries: 4
       No. of Occupations: 18
       No. of Employees: 6614 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80574
       No. of Facilities: 2284 (estimated)
       No. of Industries: 12
       No. of Occupations: 36
       No. of Employees: 85071 (estimated)
       No. of Female Employees: 59178 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***