*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : VS3040000
CHEMICAL NAME : 16,17-Seco-13-alpha-estra-1,3,5,7,9-pentaen-17-oic
acid, 3-methoxy-, (+-)-
CAS REGISTRY NUMBER : 15372-34-6
OTHER CAS REGISTRY NOS. : 32448-80-9
LAST UPDATED : 199801
DATA ITEMS CITED : 4
MOLECULAR FORMULA : C19-H22-O3
MOLECULAR WEIGHT : 298.41
WISWESSER LINE NOTATION : L B666&&TJ EO1 K2 LVQ
COMPOUND DESCRIPTOR : Reproductive Effector
SYNONYMS/TRADE NAMES :
* dl-cis-Bisdehydrodoisynolic acid methyl ether
* Doisynoestrol
* Fenociclina
* Fenocyclin
* Fenocycline
* Fenocylin
* 3-Methoxy-16,17-secoestra-1,3,5(10),6,8-pentaen-17-oic acid
* Phenocyclin
* RS 2874
* Surestrine
* Surestryl
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 17500 ng/kg
SEX/DURATION : female 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 3,387,1971
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 300 ug/kg
SEX/DURATION : female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 3,387,1971
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE : 2400 ug/kg
SEX/DURATION : female 6 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 4,15,1971
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE : 2 mg/kg
SEX/DURATION : female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
Volume(issue)/page/year: 115,101,1973
*** END OF RECORD ***