*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VN2230000
CHEMICAL NAME           : Safflower oil
CAS REGISTRY NUMBER     : 8001-23-8
OTHER CAS REGISTRY NOS. : 84988-98-7
LAST UPDATED            : 199803
DATA ITEMS CITED        : 8
COMPOUND DESCRIPTOR     : Tumorigen
                          Natural Product
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Carthamus tinctorius oil
   * Fats and Glyceridic oils, safflower
   * Oils, glyceridic, safflower
   * Safflower seed oil
   * Thistle oil
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Human
DOSE/DURATION           : 300 mg/3D (Intermittent)
REACTION SEVERITY       : Mild
REFERENCE :
   85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill,
   V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
   Volume(issue)/page/year: -,127,1977
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/24H
REACTION SEVERITY       : Mild
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 4(5),171,1985
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >50 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD691-490
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2600 mL/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-426,1994

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - A1259
       No. of Facilities: 1098 (estimated)
       No. of Industries: 19
       No. of Occupations: 26
       No. of Employees: 8496 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - A1259
       No. of Facilities: 1221 (estimated)
       No. of Industries: 11
       No. of Occupations: 18
       No. of Employees: 11307 (estimated)
       No. of Female Employees: 6108 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   NTP Carcinogenesis studies (gavage)
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-426,94

 
                            *** END OF RECORD ***