*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VV4000000
CHEMICAL NAME           : Silane, beta-(3,4-epoxycyclohexyl)ethyltrimethoxy-
CAS REGISTRY NUMBER     : 3388-04-3
LAST UPDATED            : 199712
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C11-H22-O4-Si
MOLECULAR WEIGHT        : 246.42
WISWESSER LINE NOTATION : T36 BOTJ E2-SI-O1&O1&O1
COMPOUND DESCRIPTOR     : Tumorigen
                          Organometallic
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * A 186 (coupling agent)
   * E 6250
   * Epoxycyclohexylethyl trimethoxy silane
   * beta-(3,4-Epoxycyclohexyl)ethyltrimethoxysilane
   * KBM 303
   * NUCA 186
   * S 530
   * Sila-Ace S 530
   * Silane Y-4086
   * Silicone A-186
   * Silquest A 186
   * Union carbide A-186
   * Y 4086
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Open irritation test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg
REACTION SEVERITY       : Mild
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 1/17/1972
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8 mL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JBMRBG Journal of Biomedical Materials Research.  (John Wiley & Sons, Inc.,
   605 Third Ave., New York, NY 10158)  V.1-    1967- Volume(issue)/page/year:
   8,11,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 mL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JBMRBG Journal of Biomedical Materials Research.  (John Wiley & Sons, Inc.,
   605 Third Ave., New York, NY 10158)  V.1-    1967- Volume(issue)/page/year:
   8,11,1974
 
TYPE OF TEST            : LC - Lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >290 mg/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JBMRBG Journal of Biomedical Materials Research.  (John Wiley & Sons, Inc.,
   605 Third Ave., New York, NY 10158)  V.1-    1967- Volume(issue)/page/year:
   8,11,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 6300 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 2/11/1964
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1587 gm/kg/76W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   12,579,1989

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X9076
       No. of Facilities: 367 (estimated)
       No. of Industries: 17
       No. of Occupations: 23
       No. of Employees: 15389 (estimated)
       No. of Female Employees: 3865 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***