*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : VV9100000 CHEMICAL NAME : Silicic acid, beryllium zinc salt CAS REGISTRY NUMBER : 39413-47-3 OTHER CAS REGISTRY NOS. : 63089-82-7 LAST UPDATED : 199712 DATA ITEMS CITED : 43 WISWESSER LINE NOTATION : BE ZN SI-O4 COMPOUND DESCRIPTOR : Tumorigen Mutagen SYNONYMS/TRADE NAMES : * Beryllium zinc silicate * Zinc beryllium silicate *** HEALTH HAZARD DATA *** ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 100 mg/kg/2W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Musculoskeletal - tumors REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,519,1950 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Musculoskeletal - tumors REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 20,778,1966 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 17 mg(Be)/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Musculoskeletal - tumors Tumorigenic - tumors at site of application REFERENCE : BUCABS Bulletin du Cancer. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1966- Volume(issue)/page/year: 62,49,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Musculoskeletal - tumors REFERENCE : ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS. Volume(issue)/page/year: 88,89,1969 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 500 mg/kg/10W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Musculoskeletal - tumors REFERENCE : JBSUAK Journal of Bone and Joint Surgery, British Volume. (10 Shattuck St., Boston, MA 02115) V.30- 1948- Volume(issue)/page/year: 36,543,1954 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 500 mg/kg/6W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Musculoskeletal - tumors REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 5,221,1946 *** REVIEWS *** ACGIH TLV-SUSPECTED HUMAN CARCINOGEN 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997 ACGIH TLV-TWA 0.002 mg(Be)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-Suspected human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,17,1972 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 23,143,1980 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 58,41,1993 IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 58,41,1993 IARC Cancer Review:Group 1 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 58,41,1993 TOXICOLOGY REVIEW FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 9,105,1971 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Gen Indu):8H TWA 0.002 mg(Be)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.002 mg(Be)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.002 mg(Be)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.002 mg(Be)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.002 mg(Be)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-DENMARK:TWA 0.001 mg(Be)/m3;Carcinogen JAN 1993 OEL-FINLAND:TWA 0.002 mg(Be)/m3;STEL 0.006 mg(Be)/m3;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-HUNGARY:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993 OEL-INDIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-JAPAN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 0.002 mg(Be)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.002 mg(Be)/m3 JAN 1993 OEL-POLAND:TWA 0.001 mg(Be)/m3 JAN 1993 OEL-RUSSIA:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993 OEL-SWEDEN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993 OEL-THAILAND:TWA 0.002 mg(Be)/m3;STEL 0.005 mg(Be)/m3 JAN 1993 OEL-TURKEY:TWA 0.002 mg(Be)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.002 mg(Be)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO BERYLLIUM-air:CA not to exceed 0.0005 mg(Be)/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen *** END OF RECORD ***