*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : WB0350000
CHEMICAL NAME : Sodium fluoride
CAS REGISTRY NUMBER : 7681-49-4
OTHER CAS REGISTRY NOS. : 39287-69-9
LAST UPDATED : 199806
DATA ITEMS CITED : 152
MOLECULAR FORMULA : F-Na
MOLECULAR WEIGHT : 41.99
WISWESSER LINE NOTATION : NA F
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Alcoa sodium fluoride
* Antibulit
* Cavi-trol
* Chemifluor
* Credo
* Disodium difluoride
* FDA 0101
* F1-Tabs
* Floridine
* Florocid
* Flozenges
* Fluoral
* Fluorident
* Fluoride, sodium
* Fluorid sodny
* Fluorigard
* Fluorineed
* Fluorinse
* Fluoritab
* Fluorocid
* Fluor-O-kote
* Fluorol
* Fluorure de sodium
* Flura
* Flura drops
* Flura-gel
* Flura-loz
* Flurcare
* Flursol
* Fungol B
* GEL II
* Gelution
* Gleem
* Iradicav
* Karidium
* Karigel
* Kari-rinse
* Lea-Cov
* Lemoflur
* Luride
* Luride lozi-tabs
* Luride-SF
* Nafeen
* NaFpak
* Na frinse
* Natrium fluoride
* NCI-C55221
* Nufluor
* Ossalin
* Ossin
* Pediaflor
* Pedident
* Pennwhite
* Pergantene
* Phos-Flur
* Point two
* Predent
* Rafluor
* Rescue squad
* Roach salt
* Sodium fluoride cyclic dimer
* Sodium fluorure
* Sodium hydrofluoride
* Sodium monofluoride
* SO-Flo
* Stay-Flo
* Studafluor
* Super-dent
* T-Fluoride
* Thera-flur
* Thera-flur-N
* Trisodium trifluoride
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20 mg/24H
REACTION SEVERITY : Moderate
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,20,1972
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 90 mg/kg
TOXIC EFFECTS :
Behavioral - fluid intake
Behavioral - muscle weakness
Gastrointestinal - nausea or vomiting
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
81,811,1923
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 360 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cyanosis
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
100,97,1933
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 7 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
1,886,1936
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 1662 mg/kg
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects
Lungs, Thorax, or Respiration - respiratory depression
Gastrointestinal - nausea or vomiting
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
222,816,1972
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 214 ug/kg
TOXIC EFFECTS :
Behavioral - headache
Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
RMLIAC Revue Medicale de Liege. (c/o Institute de Medicine, Rue Alex Bouvy,
13, 4020, Liege, Liege, Belgium) V.1- 1946- Volume(issue)/page/year:
12,408,1957
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 71 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Musculoskeletal - changes in teeth and supporting structures
Musculoskeletal - other changes
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
11,1361,1989
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,1033,1966
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intradermal
SPECIES OBSERVED : Human
DOSE/DURATION : 14 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis
Immunological Including Allergic - increased immune response
REFERENCE :
RMLIAC Revue Medicale de Liege. (c/o Institute de Medicine, Rue Alex Bouvy,
13, 4020, Liege, Liege, Belgium) V.1- 1946- Volume(issue)/page/year:
12,408,1957
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 52 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: UR-3490-95
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 22 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and
Development Reports. (Rochester, NY) Volume(issue)/page/year: UR-154,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,411,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 26 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - tumors
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
3,278,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 57 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SHGKA3 Shika Gakuho. Journal of Dentistry. (Tokyo Shika Daigaku Gakkai,
1-2-2 Masago, Chiba 260, Japan) V.1- 1895- Volume(issue)/page/year:
80,1519,1980
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 183,427,1936
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 38 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 27,237,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 115 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
68(3),55P-74P,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50830 ug/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 27,237,1982
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and
Development Reports. (Rochester, NY) Volume(issue)/page/year: UR-154,1951
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 155 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1349,1935
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 26600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
22,99,1965
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 14 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1349,1935
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603
Calvert Rd., College Park, MD 20740) V.1- 1908- Volume(issue)/page/year:
61,751,1968
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1349,1935
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1349,1935
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 448 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 124,133,1937
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - domestic
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NEZTAF New Zealand Veterinary Journal. (New Zealand Veterinary Assoc., POB
524, Wellington, 1, New Zealand) V.1- 1952- Volume(issue)/page/year:
30,199,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - wild bird species
DOSE/DURATION : 110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
070944) V.1- 1973- Volume(issue)/page/year: 16,483,1987
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 420 mg/kg/6W-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - somnolence (general depressed activity)
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year:
17,169,1995
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 500 mg/kg/5D-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
3,290,1961
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 603 mg/kg/26W-I
TOXIC EFFECTS :
Musculoskeletal - other changes
Nutritional and Gross Metabolic - changes in calcium
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 39(1),17,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1500 mg/kg/60D-I
TOXIC EFFECTS :
Gastrointestinal - other changes
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 37,70,1986
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 mg/kg/5H/17W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Musculoskeletal - changes in teeth and supporting structures
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 24(1),15,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 105 mg/kg/10D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 7,463,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 160 mg/kg/14D-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-393,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 21840 mg/kg/26W-C
TOXIC EFFECTS :
Musculoskeletal - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-393,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 402 mg/kg/35D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 44,21,1988
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 5460 mg/kg/78W-I
TOXIC EFFECTS :
Gastrointestinal - malabsorption
Blood - other changes
Nutritional and Gross Metabolic - changes in calcium
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 62,14,1993
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 6930 mg/kg/99W-I
TOXIC EFFECTS :
Musculoskeletal - other changes
Nutritional and Gross Metabolic - changes in calcium
Nutritional and Gross Metabolic - changes in phosphorus
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
67,573,1993
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 3650 mg/kg/1Y-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 30,388,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1327 mg/kg/30D-I
TOXIC EFFECTS :
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 5,11,1985
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 12617 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - thyroid tumors
Musculoskeletal - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-393,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 14 mg/kg/43W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 27,237,1982
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 140 mg/kg/43W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 27,237,1982
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4200 mg/kg/30W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 27,237,1982
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2190 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 27,237,1982
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4217 mg/kg/30W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 27,237,1982
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4242 mg/kg/30W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 27,237,1982
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4368 mg/kg/30W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 27,237,1982
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 87 gm/kg/97W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 27,237,1982
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 150 mg/kg
SEX/DURATION : male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
JEBIDP Journal of Environmental Biology. (Academy of Environmental Biology,
India, 657/5, Civil Lines (South), Muzaffarnagar, 251001, India) V.1-
1980- Volume(issue)/page/year: 13,55,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 221 mg/kg
SEX/DURATION : female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,
Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 101,525,1971
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 240 mg/kg
SEX/DURATION : female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
NIPOAC Nippon Shonika Gakkai Zasshi. Journal of the Japanese Pediatrics
Society. (Nippon Shonika Gakkai, 1-29-8 Shinjuku, Shinjuku-ku, Tokyo 160,
Japan) V.55- 1951- Volume(issue)/page/year: 73,1900,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 128 mg/kg
SEX/DURATION : female 85 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
CHPLAB Zhonghua Binglixue Zazhi. (China International Book Trading
Corporation, POB 2820, Beijing, The Peoples Republic of China) V.1-10,
1955-66. (Suspended 1967-81); V.11- 1982- Volume(issue)/page/year:
18,290,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 255 mg/kg
SEX/DURATION : female 85 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
CHPLAB Zhonghua Binglixue Zazhi. (China International Book Trading
Corporation, POB 2820, Beijing, The Peoples Republic of China) V.1-10,
1955-66. (Suspended 1967-81); V.11- 1982- Volume(issue)/page/year:
18,290,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 9 mg/kg
SEX/DURATION : female 10-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
AOBIAR Archives of Oral Biology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1959- Volume(issue)/page/year:
17,371,1972
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 90 mg/kg
SEX/DURATION : female 10-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
AOBIAR Archives of Oral Biology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1959- Volume(issue)/page/year:
17,371,1972
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intratesticular
SPECIES OBSERVED : Rodent - rat
DOSE : 400 ug/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year:
5,505,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 1240 mg/kg
SEX/DURATION : male 8 week(s) pre-mating
female 8 week(s) pre-mating - 5 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,
Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 103,1319,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 620 mg/kg
SEX/DURATION : multigenerations
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,
Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 103,1319,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 5600 ug/kg
SEX/DURATION : lactating female 14 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - skin and skin
appendages
REFERENCE :
32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York,
Springer, 1975 Volume(issue)/page/year: -,83,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 300 ng/kg
SEX/DURATION : male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
FLUOA4 Fluoride. (International Soc. for Fluoride Research, Inc., POB 692,
Warren, MI 48090) V.3- 1970- Volume(issue)/page/year: 25,71,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 8800 mg/kg
SEX/DURATION : male 2.4 year(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 92,353,1991
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 mg/plate
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK.
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
Volume(issue)/page/year: 16(6),41,1982
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 86 mg/L
REFERENCE :
WATRAG Water Research. (Pergamon Press Ltd., Headington Hill Hall, Oxford
OX3 0BW, UK) V.1- 1967- Volume(issue)/page/year: 14,1613,1980
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 5 pph/24H
REFERENCE :
FLUOA4 Fluoride. (International Soc. for Fluoride Research, Inc., POB 692,
Warren, MI 48090) V.3- 1970- Volume(issue)/page/year: 6,113,1973
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Multiple routes
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 60 ug/L
REFERENCE :
GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo
Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 15,36,1976
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 139,193,1984
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION : 200 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 140,43,1984
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 279,109,1992
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 20 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 139,193,1984
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 20 mg/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 2,497,1987
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 952 umol/L
REFERENCE :
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview
Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,353,1991
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 440 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 196,61,1988
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,59,1996
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 36 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 172,77,1986
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Subcutaneous
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 200 mmol/L
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 35,71,1979
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - rat Bone marrow
DOSE/DURATION : 100 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,67,1995
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,7,1996
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 40 mg/kg
REFERENCE :
ICHUDW Yichuan. Heredity. (China International Book Trading Corp., POB
2820, Beijing, Peop. Rep. China) V.1- 1979- Volume(issue)/page/year:
8(5),39,1986
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 10 mg/kg
REFERENCE :
CARYAB Caryologia. (Via G. LaPira 4, 50121 Florence, Italy) V.1- 1948-
Volume(issue)/page/year: 40,79,1987
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 300 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 187,165,1987
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 10 mg/kg
REFERENCE :
CARYAB Caryologia. (Via G. LaPira 4, 50121 Florence, Italy) V.1- 1948-
Volume(issue)/page/year: 40,79,1987
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 1 ppm/3W (Continuous)
REFERENCE :
FLUOA4 Fluoride. (International Soc. for Fluoride Research, Inc., POB 692,
Warren, MI 48090) V.3- 1970- Volume(issue)/page/year: 15,110,1982
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 200 mg/L
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
29,230,1974
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Subcutaneous
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 40 mg/kg
REFERENCE :
CARYAB Caryologia. (Via G. LaPira 4, 50121 Florence, Italy) V.1- 1948-
Volume(issue)/page/year: 40,79,1987
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 40 mg/kg
REFERENCE :
ICHUDW Yichuan. Heredity. (China International Book Trading Corp., POB
2820, Beijing, Peop. Rep. China) V.1- 1979- Volume(issue)/page/year:
8(5),39,1986
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 20 mg/L/16H
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 1,157,1986
TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 10 mg/kg/5D (Continuous)
REFERENCE :
CARYAB Caryologia. (Via G. LaPira 4, 50121 Florence, Italy) V.1- 1948-
Volume(issue)/page/year: 40,79,1987
TYPE OF TEST : Micronucleus test
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 367,99,1996
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 25 mg/L
REFERENCE :
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview
Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 2,103,1988
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 10 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
44,938,1984
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human Lung
DOSE/DURATION : 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 279,109,1992
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 279,109,1992
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 50 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
44,938,1984
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 25 mg/L
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 52,889,1987
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 50 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 223,191,1989
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 80 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
44,938,1984
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 66700 ug/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-393,1990
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Mammal - domestic Cells - not otherwise specified
DOSE/DURATION : 25 mg/L
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
29,230,1974
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Mammal - species unspecified Lung
DOSE/DURATION : 300 umol/L
REFERENCE :
HKXUDL Huanjing Kexue Xuebao. Environmental Sciences Journal. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-
1981- Volume(issue)/page/year: 3,94,1983
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Mammal - cattle Cells - not otherwise specified
DOSE/DURATION : 10 mg/L
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
29,230,1974
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 4 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 301,183,1993
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Mammal - species unspecified Lung
DOSE/DURATION : 3 mmol/L
REFERENCE :
HKXUDL Huanjing Kexue Xuebao. Environmental Sciences Journal. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-
1981- Volume(issue)/page/year: 3,94,1983
*** REVIEWS ***
ACGIH TLV-TWA 2.5 mg(F)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 27,237,1982
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 27,237,1982
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,208,1987
TOXICOLOGY REVIEW
ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For
publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966
TOXICOLOGY REVIEW
AMSSAQ Acta Medica Scandinavica, Supplement. (Almqvist & Wiksell, POB
45150, S-10430 Stockholm, Sweden) No.1-730, 1921-88.
Volume(issue)/page/year: 400,5,1963
TOXICOLOGY REVIEW
FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub
lisher information, see FSINDR. Volume(issue)/page/year: 2,67,1973
TOXICOLOGY REVIEW
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73.
For publisher information, see IOHSA5. Volume(issue)/page/year:
19,535,1950
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 2.5 mg(F)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,116,1971
OSHA PEL (Gen Indu):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 2.5 mg(F)/m3 JAN 1993
OEL-BELGIUM:TWA 2.5 mg(F)/m3 JAN 1993
OEL-DENMARK:TWA 2.5 mg(F)/m3 JAN 1993
OEL-FINLAND:TWA 2.5 mg(F)/m3 JAN 1993
OEL-FRANCE:TWA 2 mg/m3 JAN 1993
OEL-FRANCE:TWA 2.5 mg(F)/m3 JAN 1993
OEL-GERMANY:TWA 2.5 mg(F)/m3 JAN 1993
OEL-HUNGARY:TWA 1 mg(F)/m3;STEL 2 mg(F)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 2.5 mg(F)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 2.5 mg(F)/m3 JAN 1993
OEL-POLAND:TWA 1 mg(F)/m3 JAN 1993
OEL-RUSSIA:TWA 0.2 mg/m3;STEL 1 mg/m3 JAN 1993
OEL-SWEDEN:TWA 2 mg(F)/m3 JAN 1993
OEL-SWITZERLAND:TWA 1.8 ppm (1.5 mg(F)/m3);STEL 9.0 ppm JAN 1993
OEL-THAILAND:TWA 2.5 mg(F)/m3 JAN 1993
OEL-TURKEY:TWA 2.5 mg(F)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 2.5 mg(F)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO FLUORIDES, INORGANIC-air:10H TWA 2.5 mg(F)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84425
No. of Facilities: 3763 (estimated)
No. of Industries: 50
No. of Occupations: 50
No. of Employees: 25059 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84425
No. of Facilities: 3970 (estimated)
No. of Industries: 83
No. of Occupations: 69
No. of Employees: 84776 (estimated)
No. of Female Employees: 26602 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-nondisjunction; N
crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Negative: In vivo SCE-nonhuman; S cerevisiae gene
conversion
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-partial sex chrom.
loss
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NTP Carcinogenesis Studies (oral);equivocal evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-393,90
NTP Carcinogenesis Studies (oral);no evidence:mouse
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-393,90
*** END OF RECORD ***