*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WG0780000
CHEMICAL NAME           : Songorine
CAS REGISTRY NUMBER     : 509-24-0
BEILSTEIN REFERENCE NO. : 0045107
REFERENCE               : 4-21-00-06538 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C22-H31-N-O3
MOLECULAR WEIGHT        : 357.54
WISWESSER LINE NOTATION : T G5 D665 B6 B6/G-J/CL/LR A G- 5BBCCJ R CX FV HY JX
                          MNTJ HU1 IQ M2 O1 RQ
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * Bullatine
   * 7,20-Cycloveatchan-12-one, 21-ethyl-1,15-dihydroxy-4-methyl-16-methylene, 
    (1alpha,15beta)-
   * Napellonine
   * Songorin
   * Xuan-Wu 2
   * Zongorine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 408 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOETD7 Journal of Ethnopharmacology.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1979-  Volume(issue)/page/year:
   4,247,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1575 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOETD7 Journal of Ethnopharmacology.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1979-  Volume(issue)/page/year:
   4,247,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 485 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOETD7 Journal of Ethnopharmacology.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1979-  Volume(issue)/page/year:
   4,247,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 630 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOETD7 Journal of Ethnopharmacology.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1979-  Volume(issue)/page/year:
   4,247,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTYAD8 Zhongcaoyao.  Chinese Traditional and Herbal Medicine.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11-
      1980-  Volume(issue)/page/year: 15,5,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 142 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
   11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
   11,1374,1989
 
                            *** END OF RECORD ***