*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WG2933500
CHEMICAL NAME           : Sorbitan, monostearate
CAS REGISTRY NUMBER     : 1338-41-6
LAST UPDATED            : 199710
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C24-H46-O6
MOLECULAR WEIGHT        : 430.70
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Anhydrosorbitol stearate
   * Arlacel 60
   * Armotan MS
   * Crill 3
   * Crill K 3
   * Drewsorb 60
   * Durtan 60
   * Emsorb 2505
   * D-Glucitol, anhydro-, monooctadecanoate
   * Glycomul S
   * Hodag SMS
   * Ionet S 60
   * Liposorb S
   * Liposorb S-20
   * Montane 60
   * MS 33
   * MS 33F
   * Newcol 60
   * Nikkol SS 30
   * Nissan nonion SP 60
   * Nonion SP 60
   * Nonion SP 60R
   * Rikemal S 250
   * Sorbitan C
   * Sorbitan, monooctadecanoate
   * Sorbitan stearate
   * Sorbon S 60
   * Sorgen 50
   * Span 55
   * Span 60
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 800 ug
REACTION SEVERITY       : Mild
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 4(3),65,1985
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 31 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FOREAE Food Research.  (Champaign, IL)  V.1-25, 1936-60.  For publisher
   information, see JFDSAZ.  Volume(issue)/page/year: 21,348,1956
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2730 gm/kg/2Y-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Kidney, Ureter, Bladder - changes in bladder weight
   Related to Chronic Data - death
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   1,315,1959
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 635 gm/kg
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   JONUAI Journal of Nutrition.  (Subscription Dept., 9650 Rockville Pike,
   Bethesda, MD 20014) V.1-    1928-  Volume(issue)/page/year: 60,489,1956
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1270 gm/kg
SEX/DURATION            : female 84 day(s) pre-mating  - 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   JONUAI Journal of Nutrition.  (Subscription Dept., 9650 Rockville Pike,
   Bethesda, MD 20014) V.1-    1928-  Volume(issue)/page/year: 60,489,1956

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 4(3),65,1985

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 81999
       No. of Facilities: 693 (estimated)
       No. of Industries: 15
       No. of Occupations: 25
       No. of Employees: 14579 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 81999
       No. of Facilities: 6199 (estimated)
       No. of Industries: 63
       No. of Occupations: 72
       No. of Employees: 189741 (estimated)
       No. of Female Employees: 71370 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8797
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***