*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WG9040000
CHEMICAL NAME           : Spigelia anthelmia L., extract
SUBSTANCE DEFINITION :
   Plant belonging to the family Loganiaceae
REFERENCE :
   IJCREE International Journal of Crude Drug Research.  (Swets & Zeitlinger
   B.V., POB 825, 2160 SZ Lisse, Netherlands)  V.20-    1982-
LAST UPDATED            : 199506
DATA ITEMS CITED        : 1
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Lombricera, extract
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 222 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - analgesia
REFERENCE :
   IJCREE International Journal of Crude Drug Research.  (Swets & Zeitlinger
   B.V., POB 825, 2160 SZ Lisse, Netherlands)  V.20-    1982-
   Volume(issue)/page/year: 23,17,1985
 
                            *** END OF RECORD ***