*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WG9863500
CHEMICAL NAME           : Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2-carboxami
                          de, 2,3-dihydro-2',5'-dioxo-6-fluoro-, (2S-cis)-
CAS REGISTRY NUMBER     : 136087-85-9
LAST UPDATED            : 199712
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C12-H10-F-N3-O4
MOLECULAR WEIGHT        : 279.25
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   (2S,4S)-6-Fluoro-2',5'-dioxospiro(3,4-dihydro-2H-1-benzopyran-4,4'-imida
     zolidine)-2-carboxamid
   * SNK 860
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EXMDA4 International Congress Series--Excerpta Medica.  (Excerpta Medica,
   Inc., POB 3085, Princeton, NJ 08540)  No.1-    1952-
   Volume(issue)/page/year: 913,89,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EXMDA4 International Congress Series--Excerpta Medica.  (Excerpta Medica,
   Inc., POB 3085, Princeton, NJ 08540)  No.1-    1952-
   Volume(issue)/page/year: 913,89,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EXMDA4 International Congress Series--Excerpta Medica.  (Excerpta Medica,
   Inc., POB 3085, Princeton, NJ 08540)  No.1-    1952-
   Volume(issue)/page/year: 913,89,1990
 
                            *** END OF RECORD ***