*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WH0100000
CHEMICAL NAME           : Spiro(1H-2-benzoxepin-9,2'-oxirane)-4-carboxylic
                          acid, 3,5a,6,7,8,9a-hexahydro-6-isopropyl- 1-oxo-
CAS REGISTRY NUMBER     : 57710-57-3
OTHER CAS REGISTRY NOS. : 84502-40-9
BEILSTEIN REFERENCE NO. : 5091359
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C15-H20-O5
MOLECULAR WEIGHT        : 280.35
WISWESSER LINE NOTATION : T67 BVO KX EUTJ EVQ HY1&1 K-& BT3OX CHJ
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Avocettin
   * Heptelidic acid
   * Koningic acid
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JKXXAF Japanese Kokai Tokyo Koho Patents.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year:
   #82-146793
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 32 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 33,468,1980
 
                            *** END OF RECORD ***