*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WH0204487
CHEMICAL NAME           : Spiro(cyclopropane-1,5'(5H)-inden)-7'(6'H)-one,
                          6'-hydroxy-3'-(hydroxymethyl)-2',4',6'- trimethyl-,
                          (R)-
CAS REGISTRY NUMBER     : 158440-71-2
LAST UPDATED            : 199712
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C15-H18-O3
MOLECULAR WEIGHT        : 246.33
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * Acylfulvene, 6-(hydroxymethyl)-
   * HMAF
   * 6-(Hydroxymethyl)acylfulvene
   * MGI 114
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >6610 ug/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Blood - changes in bone marrow (not otherwise specified)
   Blood - changes in other cell count (unspecified)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year: 36(1,
   Pt 2),180,1997
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Blood - thrombocytopenia
   Blood - changes in bone marrow (not otherwise specified)
   Blood - changes in other cell count (unspecified)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year: 36(1,
   Pt 2),180,1997
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 20339 ug/kg/5D-I
TOXIC EFFECTS :
   Cardiac - other changes
   Blood - changes in bone marrow (not otherwise specified)
   Blood - changes in other cell count (unspecified)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year: 36(1,
   Pt 2),180,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 3 mg/kg/5D-I
TOXIC EFFECTS :
   Blood - thrombocytopenia
   Blood - changes in bone marrow (not otherwise specified)
   Blood - changes in other cell count (unspecified)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year: 36(1,
   Pt 2),180,1997
 
                            *** END OF RECORD ***