*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WH6860000
CHEMICAL NAME           : Stannane, chlorotriphenyl-
CAS REGISTRY NUMBER     : 639-58-7
LAST UPDATED            : 199712
DATA ITEMS CITED        : 35
MOLECULAR FORMULA       : C18-H15-Cl-Sn
MOLECULAR WEIGHT        : 385.47
WISWESSER LINE NOTATION : G-SN-R&R&R
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Drug
                          Organometallic
                          Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Aquatin
   * Aquatin 20 EC
   * Brestanol
   * Chlorotriphenylstannane
   * Chlorotriphenyltin
   * Fentin chloride
   * GC 8993
   * General chemicals 8993
   * HOE 2872
   * LS 4442
   * Phenostat-C
   * TPTC
   * Tinmate
   * Triphenylchlorostannane
   * Triphenylchlorotin
   * Triphenyltin chloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMCHA2 Farm Chemicals Handbook.  (Meister Pub., 37841 Euclid Ave.,
   Willoughy, OH 44094)  Volume(issue)/page/year: -,C314,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMCHA2 Farm Chemicals Handbook.  (Meister Pub., 37841 Euclid Ave.,
   Willoughy, OH 44094)  Volume(issue)/page/year: -,C314,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 21500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JICSAH Journal of the Indian Chemical Society.  (Indian Chemical Soc., 92,
   Acharya Prafulla Chandra Rd., Calcutta 700009, India)  V.5-     1928-
   Volume(issue)/page/year: 67,740,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#01649
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 210 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AXVMAW Archiv fuer Experimentelle Veterinaermedizin.  (S. Hirzel Verlag,
   Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.)  V.6-    1952-
   Volume(issue)/page/year: 40,307,1986
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 210 mg/kg/2W-C
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
   Endocrine - changes in thymus weight
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   81,274,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 20 mg/kg/10D-I
TOXIC EFFECTS :
   Endocrine - other changes
   Endocrine - changes in thymus weight
REFERENCE :
   AXVMAW Archiv fuer Experimentelle Veterinaermedizin.  (S. Hirzel Verlag,
   Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.)  V.6-    1952-
   Volume(issue)/page/year: 40,307,1986
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 380 mg/kg
SEX/DURATION            : male 19 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   JEENAI Journal of Economic Entomology.  (Entomological Soc. of America, 4603
   Calvert Rd., College Park, MD 20740)  V.1-    1908- Volume(issue)/page/year:
   61,32,1968
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 30 nmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 246,109,1991
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 60 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 300,5,1993

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 0.1 mg(Sn)/m3;STEL 0.2 mg/m3 (skin)
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

   ACGIH TLV-Not classifiable as a human carcinogen
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 0.1 mg(Sn)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   3,258,1971

   OSHA PEL (Gen Indu):8H TWA 0.1 mg(Sn)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Construc):8H TWA 0.1 mg(Sn)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Shipyard):8H TWA 0.1 mg(Sn)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

   OSHA PEL (Fed Cont):8H TWA 0.1 mg(Sn)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   41,50-204.50,1994

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-AUSTRALIA:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
   
   OEL-BELGIUM:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
   
   OEL-DENMARK:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
   
   OEL-FINLAND:TWA 0.1 mg(Sn)/m3;STEL 0.3 mg(Sn)/m3;Skin JAN 1993
   
   OEL-FRANCE:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3 JAN 1993
   
   OEL-GERMANY:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
   
   OEL-HUNGARY:STEL 0.1 mg(Sn)/m3;Skin JAN 1993
   
   OEL-THE NETHERLANDS:TWA 0.1 mg(Sn)/m3;Skin JAN 1993
   
   OEL-THE PHILIPPINES:TWA 0.1 mg(Sn)/m3 JAN 1993
   
   OEL-SWEDEN:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993
   
   OEL-SWITZERLAND:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993
   
   OEL-THAILAND:TWA 0.1 mg(Sn)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO ORGANOTIN COMPOUND-air:10H TWA 0.1 mg(Sn)/m3
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***