*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WH1314300
CHEMICAL NAME           : Spiro(isobenzofuran-1(3H),9'-xanthen)-3-one,
                          3',6'-diamino-
CAS REGISTRY NUMBER     : 509-72-8
BEILSTEIN REFERENCE NO. : 0045341
REFERENCE               : 0-19-00-00342 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C20-H14-N2-O3
MOLECULAR WEIGHT        : 330.36
WISWESSER LINE NOTATION : T C666 BO IXJ EZ MZ I-& DT56 BVOXJ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * o-(6-Amino-3-imino-3H-xanthen-9-yl) benzoic acid
   * Benzoic acid, o-(b-amino-3-imino-3H-xanthen-9-yl)-
   * 3',6'-Diaminofluoran
   * 3',6'-Diaminospiro(isobenzofuran-1)
   * 3',6'-Fluorandiamine
   * Fluoran, 3',6'-diamino-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,696,1961
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50400 mg/kg/12W-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Kidney, Ureter, Bladder - changes in bladder weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,696,1961
 
                            *** END OF RECORD ***