*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WI2800000
CHEMICAL NAME           : Stearic acid
CAS REGISTRY NUMBER     : 57-11-4
BEILSTEIN REFERENCE NO. : 0608585
REFERENCE               : 4-02-00-01206 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 16
MOLECULAR FORMULA       : C18-H36-O2
MOLECULAR WEIGHT        : 284.54
WISWESSER LINE NOTATION : QV17
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Century 1240
   * Cetylacetic acid
   * Dar-chem 14
   * Emersol 120
   * Emersol 132
   * Emersol 150
   * Formula 300
   * Glycon DP
   * Glycon S-70
   * Glycon S-80
   * Glycon S-90
   * Glycon TP
   * Groco 54
   * Groco 55
   * Groco 55L
   * Groco 58
   * Groco 59
   * Hydrofol acid 1655
   * Hydrofol acid 1855
   * Hydrofol 1895
   * 1-Heptadecanecarboxylic acid
   * HY-Phi 1199
   * HY-Phi 1205
   * HY-Phi 1303
   * HY-Phi 1401
   * Hystrene 80
   * Hystrene 4516
   * Hystrene 5016
   * Hystrene 7018
   * Hystrene 9718
   * Industrene 5016
   * Industrene 8718
   * Industrene 9018
   * KAM 1000
   * KAM 2000
   * KAM 3000
   * Neo-fat 18
   * Neo-fat 18-S
   * Neo-fat 18-53
   * Neo-fat 18-54
   * Neo-fat 18-55
   * Neo-fat 18-59
   * Neo-fat 18-61
   * Octadecanoic acid
   * n-Octadecanoic acid
   * Pearl stearic
   * Stearex beads
   * Stearic acid
   * Stearophanic acid
   * Tegostearic 254
   * Tegostearic 255
   * Tegostearic 272
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Human
DOSE/DURATION           : 75 mg/3D (Intermittent)
REACTION SEVERITY       : Mild
REFERENCE :
   85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill,
   V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
   Volume(issue)/page/year: -,127,1977
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/24H
REACTION SEVERITY       : Moderate
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 17,383,1979
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4640 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 6(3),321,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 21500 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   18,141,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   18,141,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 17,383,1979
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 313 gm/kg/30W-C
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 14,196,1995
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   17,127,1963

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 21,100,1960

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 69740
       No. of Facilities: 31794 (estimated)
       No. of Industries: 220
       No. of Occupations: 159
       No. of Employees: 541742 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X7032
       No. of Facilities: 136 (estimated)
       No. of Industries: 3
       No. of Occupations: 11
       No. of Employees: 9034 (estimated)
       No. of Female Employees: 7670 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 69740
       No. of Facilities: 34970 (estimated)
       No. of Industries: 239
       No. of Occupations: 165
       No. of Employees: 1123118 (estimated)
       No. of Female Employees: 568888 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***