*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : WI2800000 CHEMICAL NAME : Stearic acid CAS REGISTRY NUMBER : 57-11-4 BEILSTEIN REFERENCE NO. : 0608585 REFERENCE : 4-02-00-01206 (Beilstein Handbook Reference) LAST UPDATED : 199710 DATA ITEMS CITED : 16 MOLECULAR FORMULA : C18-H36-O2 MOLECULAR WEIGHT : 284.54 WISWESSER LINE NOTATION : QV17 COMPOUND DESCRIPTOR : Tumorigen Mutagen Primary Irritant SYNONYMS/TRADE NAMES : * Century 1240 * Cetylacetic acid * Dar-chem 14 * Emersol 120 * Emersol 132 * Emersol 150 * Formula 300 * Glycon DP * Glycon S-70 * Glycon S-80 * Glycon S-90 * Glycon TP * Groco 54 * Groco 55 * Groco 55L * Groco 58 * Groco 59 * Hydrofol acid 1655 * Hydrofol acid 1855 * Hydrofol 1895 * 1-Heptadecanecarboxylic acid * HY-Phi 1199 * HY-Phi 1205 * HY-Phi 1303 * HY-Phi 1401 * Hystrene 80 * Hystrene 4516 * Hystrene 5016 * Hystrene 7018 * Hystrene 9718 * Industrene 5016 * Industrene 8718 * Industrene 9018 * KAM 1000 * KAM 2000 * KAM 3000 * Neo-fat 18 * Neo-fat 18-S * Neo-fat 18-53 * Neo-fat 18-54 * Neo-fat 18-55 * Neo-fat 18-59 * Neo-fat 18-61 * Octadecanoic acid * n-Octadecanoic acid * Pearl stearic * Stearex beads * Stearic acid * Stearophanic acid * Tegostearic 254 * Tegostearic 255 * Tegostearic 272 *** HEALTH HAZARD DATA *** ** SKIN/EYE IRRITATION DATA ** TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Human DOSE/DURATION : 75 mg/3D (Intermittent) REACTION SEVERITY : Mild REFERENCE : 85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977 TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 500 mg/24H REACTION SEVERITY : Moderate REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,383,1979 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4640 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(3),321,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 21500 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 18,141,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 18,141,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,383,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 313 gm/kg/30W-C TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 14,196,1995 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 17,127,1963 *** REVIEWS *** TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,100,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 69740 No. of Facilities: 31794 (estimated) No. of Industries: 220 No. of Occupations: 159 No. of Employees: 541742 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7032 No. of Facilities: 136 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 9034 (estimated) No. of Female Employees: 7670 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 69740 No. of Facilities: 34970 (estimated) No. of Industries: 239 No. of Occupations: 165 No. of Employees: 1123118 (estimated) No. of Female Employees: 568888 (estimated) *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9 EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 *** END OF RECORD ***