*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WJ6127000
CHEMICAL NAME           : 2,2'-Stilbenedisulfonic acid,
                          4,4'-bis((4-anilino-6-((2-hydroxyethyl)methylamino)-s
                          -triazin- 2-yl)amino)-, disodium salt
CAS REGISTRY NUMBER     : 13863-31-5
LAST UPDATED            : 199701
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C38-H38-N12-O8-S2.2Na
MOLECULAR WEIGHT        : 900.98
WISWESSER LINE NOTATION : T6N CN ENJ BN1&2Q DMR& FMR CSWO D1U1R BSWO DM- BT6N
                          CN ENJ DN1&2Q FMR &-NA- 2
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Phorwhite RKH
   * Tinopal 5BM
   * Tinopal 5BM-XC
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg
REACTION SEVERITY       : Moderate
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   27,494,1974
 
TYPE OF TEST            : Rinsed with water
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/2S
REACTION SEVERITY       : Mild
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   27,494,1974
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CCECAU Criticial Reviews in Environmental Control.  (Chemical Rubber
   Company, Cleveland, OH) V.1-   1970-  Volume(issue)/page/year: 7,91,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CCECAU Criticial Reviews in Environmental Control.  (Chemical Rubber
   Company, Cleveland, OH) V.1-   1970-  Volume(issue)/page/year: 7,91,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MVCRB3 MVC-Report.  (Stockholm, Sweden)  No.1-2, 1972-73.  Discontinued.
   Volume(issue)/page/year: 2,193,1973
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 22500 mg/kg/90D-I
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   27,494,1974
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 110 mg/kg
SEX/DURATION            : female 6-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   27,494,1974

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - T1017
       No. of Facilities: 21 (estimated)
       No. of Industries: 1
       No. of Occupations: 4
       No. of Employees: 580 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - T1017
       No. of Facilities: 1853 (estimated)
       No. of Industries: 13
       No. of Occupations: 23
       No. of Employees: 19843 (estimated)
       No. of Female Employees: 8455 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***