*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : WJ6147000
CHEMICAL NAME : 2,2'-Stilbenedisulfonic acid,
4,4'-bis((4-anilino-6-morpholino-s-triazin-2-yl)amino
)-, disodium salt
CAS REGISTRY NUMBER : 16090-02-1
OTHER CAS REGISTRY NOS. : 12646-20-7
LAST UPDATED : 199710
DATA ITEMS CITED : 17
MOLECULAR FORMULA : C40-H38-N12-O8-S2.2Na
MOLECULAR WEIGHT : 925.00
WISWESSER LINE NOTATION : T6N CN ENJ BMR& D- AT6N DOTJ& FMR CSWO D1U1R BSWO DM-
BT6N CN ENJ DMR& F- AT6N DOTJ &-NA- 2
COMPOUND DESCRIPTOR : Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Belotex KD
* 4,4'-Bis((4-anilino-6-morpholino-1,3,5-triazine-2-yl)amino)stilbene
2,2-disulfonate 2Na
* Blankophor BBH
* Blankophor MBBH
* Calcofluor White RC
* C.I. Fluorescent Brightener 71
* C.I. Fluorescent Brightener 244
* C.I. Fluorescent Brightener 250
* C.I. Fluorescent Brightener 260
* Disodium
4,4'-bis((4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino)stilbene-2,2'-
disulfonate
* FBA-260
* Heliofor 3BC
* Heliofor BDC
* Hiltamine Arctic White DML
* Leukopur PAM
* MBBH 766
* Mikephor TB
* Phorwite MBBH 766
* Stralex MD
* Tinopal AMS
* Tinopal DMS-X
* Tinopal EMS
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg
REACTION SEVERITY : Mild
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
27,494,1974
TYPE OF TEST : Rinsed with water
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/2S
REACTION SEVERITY : Mild
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
27,494,1974
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CCECAU Criticial Reviews in Environmental Control. (Chemical Rubber
Company, Cleveland, OH) V.1- 1970- Volume(issue)/page/year: 7,91,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.9- 1966- Volume(issue)/page/year:
29(2),24,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
Volume(issue)/page/year: 36(1-4),10,1989
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CCECAU Criticial Reviews in Environmental Control. (Chemical Rubber
Company, Cleveland, OH) V.1- 1970- Volume(issue)/page/year: 7,91,1977
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CCECAU Criticial Reviews in Environmental Control. (Chemical Rubber
Company, Cleveland, OH) V.1- 1970- Volume(issue)/page/year: 7,91,1977
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
27,494,1974
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CCECAU Criticial Reviews in Environmental Control. (Chemical Rubber
Company, Cleveland, OH) V.1- 1970- Volume(issue)/page/year: 7,91,1977
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 21 gm/kg/21D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in kidney weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.9- 1966- Volume(issue)/page/year:
29(2),24,1986
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M4765
No. of Facilities: 38 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 759 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M4765
No. of Facilities: 25 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 414 (estimated)
No. of Female Employees: 279 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; In vitro
SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***