*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WK1972000
CHEMICAL NAME           : D-Streptamine,
                          O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(3-d
                          eoxy-4-C-methyl-3-
                          (methylamino)-beta-L-arabinopyranosyl-(1-6))-N(sup
                          1)-(3-amino-2-hydroxy-1-oxopropyl)- 2-deoxy-, (S)-
CAS REGISTRY NUMBER     : 58152-03-7
BEILSTEIN REFERENCE NO. : 4896716
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C22-H43-N5-O12
MOLECULAR WEIGHT        : 569.70
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * HAPA-B
   * HAPA-gentamycin B
   * Isepamicin
   * Sch 21420
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 330 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 29,543,1986
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3150 mg/kg/21D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - urine volume increased
   Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   33(Suppl 5),47,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 5600 mg/kg/4W-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Ear) - changes in vestibular functions
   Sense Organs and Special Senses (Ear) - changes in cochlear structure or
   function
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   33(Suppl 5),90,1985
 
                            *** END OF RECORD ***