*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WK1975000
CHEMICAL NAME           : D-Streptamine,
                          O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6
                          -diamino-2,6-dideoxy-
                          alpha-D-glucopyranosyl-(1-6))-2-deoxy-
CAS REGISTRY NUMBER     : 4696-76-8
BEILSTEIN REFERENCE NO. : 0061646
REFERENCE               : 4-18-00-07631 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C18-H37-N5-O10
MOLECULAR WEIGHT        : 483.60
WISWESSER LINE NOTATION : T6OTJ CZ DQ EQ F1Z BO- BL6TJ AZ CQ EZ DO- BT6OTJ CQ
                          DZ EQ F1Q
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Aminodeoxykanamycin
   * 2'-Amino-2'-deoxykanamycin
   * Bekanamycin
   * Kanamycin B
   * Kanendomycin
   * KDM
   * Nebramycin factor 5
   * Nebramycin V
   * NK 1006
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 1,159,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 1,159,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 132 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 27,677,1974

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis

 
                            *** END OF RECORD ***