*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WK1979000
CHEMICAL NAME           : D-Streptamine,
                          O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6
                          -diamino-2,3,4,6-
                          tetradeoxy-alpha-D-erythro-hexopyranosyl-(1-4))-N(sup
                          1)-(4-amino-2-hydroxy-1-oxobutyl)- 2-deoxy-, (S)-
CAS REGISTRY NUMBER     : 51025-85-5
LAST UPDATED            : 199606
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C22-H44-N6-O10
MOLECULAR WEIGHT        : 552.72
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Arbekacin
   * Haberacin
   * HBK
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 588 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 27,1905,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 29,543,1986
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 64 mg/kg/4D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - other changes in urine composition
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   42,200,1995
 
                            *** END OF RECORD ***