*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : WM9800000 CHEMICAL NAME : Succinic acid, monoethyl ester, monoester with erythromycin CAS REGISTRY NUMBER : 1264-62-6 OTHER CAS REGISTRY NOS. : 41342-53-4 BEILSTEIN REFERENCE NO. : 0077638 REFERENCE : 4-18-00-07416 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C43-H75-N-O16 MOLECULAR WEIGHT : 862.19 WISWESSER LINE NOTATION : T-14-VO GVTJ C2 DQ D1 EQ F1 H1 JQ J1 L1 N1 KO- BT6OTJ CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO1 D1 COMPOUND DESCRIPTOR : Drug Human SYNONYMS/TRADE NAMES : * Erythrocin ethyl succinate * Erythromycin, ethyl succinate * Erythromycin, mono(ethyl succinate) * Pediamycin *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 420 mg/kg/7D-I TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Liver - other changes REFERENCE : CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911- Volume(issue)/page/year: 129,411,1983 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 5714 ug/kg TOXIC EFFECTS : Behavioral - ataxia REFERENCE : AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 10,616,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4167 mg/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 9,445,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,126,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0949 No. of Facilities: 113 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3065 (estimated) No. of Female Employees: 1433 (estimated) *** END OF RECORD ***