*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : WN2800000
CHEMICAL NAME : Succinimide, 2-ethyl-2-methyl-
CAS REGISTRY NUMBER : 77-67-8
BEILSTEIN REFERENCE NO. : 0117054
REFERENCE : 5-21-09-00595 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 18
MOLECULAR FORMULA : C7-H11-N-O2
MOLECULAR WEIGHT : 141.19
WISWESSER LINE NOTATION : T5VMVTJ D2 D1
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Aethosuximide
* Asamid
* Atysmal
* Capitus
* CI 366
* Emeside
* Epileo Petit MAL
* Ethosuccimide
* Ethosuccinimide
* Ethosuxide
* Ethosuximide
* alpha-Ethyl-alpha-methylsuccinimide
* 3-Ethyl-3-methylpyrrolidine-2,5-dione
* 3-Ethyl-3-methyl-2,5-pyrrolidine-dione
* 2-Ethyl-2-methylsuccinimide
* Ethymal
* Etomal
* Etosuximida
* H 940
* Mesentol
* 3-Methyl-3-ethylpyrrolidine-2,5-dione
* gamma-Methyl-gamma-ethyl-succinimide
* Pemal
* Pemalin
* Pentinimid
* Petinimid
* Petnidan
* PM 671
* Pyknolepsinum
* Ronton
* Simatin(E)
* Succimal
* Succimitin
* Suxilep
* Suximal
* Suxin
* Suxinutin
* Thetamid
* Thilopemal
* Zarodan
* Zarondan-saft
* Zarontin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1530 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
EPILAK Epilepsia (New York). (Raven Press, 1185 Ave. of the Americas, New
York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1- 1959-
Volume(issue)/page/year: 4(4),66,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1325 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #4188398
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1810 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,117,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 780 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
REFERENCE :
NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall,
Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 24,427,1985
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 33300 ug/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks
In New Drugs, Proceedings of the Symposium on Toxicological Testing for
Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,
Czechoslovakia, Univerzita Karlova, 1979 Volume(issue)/page/year: -,59,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 66600 ug/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks
In New Drugs, Proceedings of the Symposium on Toxicological Testing for
Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,
Czechoslovakia, Univerzita Karlova, 1979 Volume(issue)/page/year: -,59,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 166 mg/kg
SEX/DURATION : female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks
In New Drugs, Proceedings of the Symposium on Toxicological Testing for
Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,
Czechoslovakia, Univerzita Karlova, 1979 Volume(issue)/page/year: -,59,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 2250 mg/kg
SEX/DURATION : female 9-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
EAMJAV East African Medical Journal. (P.O. Box 41632, Nairobi, Kenya) V.9-
1932- Volume(issue)/page/year: 60,407,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 160 mg/kg
SEX/DURATION : female 5-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc.,
P.O. Box 426, Fayetteville, NY 13066) V.1- 1973-
Volume(issue)/page/year: 36,163,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 3960 mg/kg
SEX/DURATION : female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
40,365,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 962 mg/kg
SEX/DURATION : female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
2,61,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE : 600 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
6,669,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE : 2626 mg/kg
SEX/DURATION : female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 38,438,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 48100 ug/kg
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks
In New Drugs, Proceedings of the Symposium on Toxicological Testing for
Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,
Czechoslovakia, Univerzita Karlova, 1979 Volume(issue)/page/year: -,59,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE : 18500 ug/kg
SEX/DURATION : female 6-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks
In New Drugs, Proceedings of the Symposium on Toxicological Testing for
Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,
Czechoslovakia, Univerzita Karlova, 1979 Volume(issue)/page/year: -,59,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - hamster
DOSE : 185 mg/kg
SEX/DURATION : female 6-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks
In New Drugs, Proceedings of the Symposium on Toxicological Testing for
Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,
Czechoslovakia, Univerzita Karlova, 1979 Volume(issue)/page/year: -,59,1979
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 30 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 204,623,1988
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3882
No. of Facilities: 371 (estimated)
No. of Industries: 4
No. of Occupations: 6
No. of Employees: 7032 (estimated)
No. of Female Employees: 4379 (estimated)
*** END OF RECORD ***