*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WO8575000
CHEMICAL NAME           : Sulfanilamide, N(sup 1)-amidino-
CAS REGISTRY NUMBER     : 57-67-0
LAST UPDATED            : 199701
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C7-H10-N4-O2-S
MOLECULAR WEIGHT        : 214.27
WISWESSER LINE NOTATION : ZR DSWMYZUM
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Abiguanil
   * N(sup 1)-Amidinosulfanilamide
   * 4-Amino-N-(aminoiminomethyl)benzenesulfonamide
   * p-Aminobenzenesulfonylguanidine
   * N-p-Aminobenzenesulphonylguanidine monohydrate
   * 4-Amino-N-(diaminomethylene)benzenesulfonamide
   * Benzenesulfonamide, 4-amino-N-(diaminomethylene)-
   * Aterian
   * N(sup 1)-(Diaminomethylene)sulfanilamide
   * Ganidan
   * Guamide
   * Guanicil
   * Guanidan
   * Guanidine, sulfanilyl-
   * N(sup 1)-Guanylsulfanilamide
   * Resulfon
   * RP 2275
   * Ruocid
   * Shigatox
   * Suganyl
   * Sulfaguanidine
   * Sulfaguine
   * Sulfanilguanidine
   * Sulfanilylguanidine
   * Sulfoguanidine
   * Sulfoguenil
   * Sulfoquanidine
   * Sulgin
   * Sulphaguanidine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >20 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 31(3),11,1966
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JHHBAI Bulletin of the Johns Hopkins Hospital.  (Baltimore, MD)  V.1-119,
   1889-1966.  For publisher information, see JHMJAX. Volume(issue)/page/year:
   67,163,1940
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 22500 mg/kg
SEX/DURATION            : female 1-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Fertility - abortion
REFERENCE :
   AFPEAM Archives Francaises de Pediatrie.  (Doin Editeurs, 8, Place de
   l'Odeon, F-75006 Paris, France) V.1-    1942-  Volume(issue)/page/year:
   7,180,1950
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 22500 mg/kg
SEX/DURATION            : female 1-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   AFPEAM Archives Francaises de Pediatrie.  (Doin Editeurs, 8, Place de
   l'Odeon, F-75006 Paris, France) V.1-    1942-  Volume(issue)/page/year:
   7,180,1950
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5880 mg/kg
SEX/DURATION            : male 6 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 81,259,1987

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   JMSHAO Journal of the Mount Sinai Hospital (New York).  (New York, NY)
   V.1-36, 1934-69.  For publisher information, see MSJMAZ.
   Volume(issue)/page/year: 10,343,1943

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 82004
       No. of Facilities: 28 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 700 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 82004
       No. of Facilities: 4 (estimated)
       No. of Industries: 1
       No. of Occupations: 16
       No. of Employees: 1418 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***