*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : WO9100000
CHEMICAL NAME : Sulfanilamide, N(sup 1)-(3,4-dimethyl-5-isoxazolyl)-
CAS REGISTRY NUMBER : 127-69-5
BEILSTEIN REFERENCE NO. : 0263871
REFERENCE : 4-27-00-04747 (Beilstein Handbook Reference)
LAST UPDATED : 199706
DATA ITEMS CITED : 17
MOLECULAR FORMULA : C11-H13-N3-O3-S
MOLECULAR WEIGHT : 267.33
WISWESSER LINE NOTATION : T5NOJ CMSWR DZ& D1 E1
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Alphazole
* Amidoxal
* 5-(p-Aminobenzenesulfonamido)-3,4-dimethylisoxazole
* 5-(p-Aminobenzenesulphonamide)-3,4-dimethylisoxazole
* 5-(p-Aminobenzenesulphonamido)-3,4-dimethylisoxazole
* 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulphonamide
* 5-(4-Aminophenylsulfonamido)-3,4-dimethylisoxazole
* 5-(4-Aminophenylsulphonamido)-3,4-dimethylisoxazole
* Benzenesulfonamide, 4-amino-N-(3,4-dimethyl-5-isoxazolyl)-
* Chemouag
* 3,4-Dimethylisoxazole-5-sulfanilamide
* 3,4-Dimethylisoxazole-5-sulphanilamide
* N(sup 1)-(3,4-Dimethyl-5-isoxazolyl)sulfanilamide
* N'-(3,4)Dimethylisoxazol-5-yl-sulphanilamide
* N(sup 1)-(3,4-Dimethyl-5-isoxazolyl)sulphanilamide
* 3,4-Dimethyl-5-sulfanilamidoisoxazole
* 3,4-Dimethyl-5-sulphanilamidoisoxazole
* 3,4-Dimethyl-5-sulphonamidoisoxazole
* Dorsulfan
* Entusil
* Entusul
* Gantrisin
* Gantrisine
* Gantrisona
* Gantrosan
* Isoxamin
* J-Sul
* Koro-sulf
* NCI-C50022
* Neazolin
* Neoxazol
* Norilgan-S
* Novazolo
* Novosaxazole
* NU 445
* Pancid
* Renosulfan
* Roxosul
* Roxosul tablets
* Saxosozine
* sk-Soxazole
* Sodizole
* Soxamide
* Soxisol
* Soxitabs
* Soxomide
* Stansin
* Sulbio
* Sulfadimethylisoxazole
* Sulfafurazol
* Sulfafurazole
* Sulfagan
* Sulfaisoxazole
* 5-Sulfanilamido-3,4-dimethylisoxazole
* Sulfapolar
* Sulfasoxazole
* Sulfasol
* Sulfazin
* Sulfisin
* Sulfisonazole
* Sulfisoxazol
* Sulfisoxazole
* Sulfizin
* Sulfizol
* Sulfizole
* Sulfoxol
* Suloxsol
* Sulphadimethylisoxazole
* Sulphafurazol
* Sulphafurazole
* Sulphafurazolum
* Sulphaisoxazole
* 5-Sulphanilamido-3,4-dimethyl-isoxazole
* Sulphisoxazol
* Sulphofurazole
* Sulphisoxazole
* Thiasin
* TL-Azole
* Unisulf
* Urisoxin
* Uritrisin
* Urogan
* U.S.-67
* Vagilia
* V-Sul
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,391,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 6800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 15,1441,1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,391,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988-
Volume(issue)/page/year: 4,105,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,391,1982
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 6 gm/kg
SEX/DURATION : female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 13,7,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 6 gm/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 13,7,1973
** MUTATION DATA **
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,59,1996
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 750 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
236,933,1987
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 100 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
236,933,1987
*** REVIEWS ***
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 24,275,1980
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 24,275,1980
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,347,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80541
No. of Facilities: 353 (estimated)
No. of Industries: 2
No. of Occupations: 9
No. of Employees: 4053 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80541
No. of Facilities: 258 (estimated)
No. of Industries: 2
No. of Occupations: 5
No. of Employees: 5506 (estimated)
No. of Female Employees: 3068 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Bioassay (gavage);no evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-138,79
*** END OF RECORD ***