*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : WL5075300
CHEMICAL NAME : Styrene, alpha-methyl-
CAS REGISTRY NUMBER : 98-83-9
LAST UPDATED : 199712
DATA ITEMS CITED : 40
MOLECULAR FORMULA : C9-H10
MOLECULAR WEIGHT : 118.19
WISWESSER LINE NOTATION : 1YR&U1
COMPOUND DESCRIPTOR : Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzene, (1-methylethenyl)-
* Isopropenil-benzolo
* Isopropenyl-benzeen
* Isopropenyl-benzol
* 1-Methyl-1-phenylethylene
* alpha-Methylstyreen
* alpha-Methylstyrene
* alpha-Methyl styrene
* alpha-Methyl-styrol
* alpha-Metil-stirolo
* as-Methylphenylethylene
* 2-Phenylpropene
* beta-Phenylpropene
* 2-Phenylpropylene
* beta-Phenylpropylene
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100%
REACTION SEVERITY : Moderate
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 14,387,1956
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 91 mg
REACTION SEVERITY : Mild
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 14,387,1956
** ACUTE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 600 ppm
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 14,387,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 14,387,1956
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3000 ppm
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZRAQ "Toxicology and Biochemistry of Aromatic Hydrocarbons," Gerarde, H.,
New York, Elsevier, 1960 Volume(issue)/page/year: -,131,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - cyanosis
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 28(12),14,1963
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 16 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 5/24/1977
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 3000 ppm
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZRAQ "Toxicology and Biochemistry of Aromatic Hydrocarbons," Gerarde, H.,
New York, Elsevier, 1960 Volume(issue)/page/year: -,131,1960
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15 gm/kg/30D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
Blood - changes in leukocyte (WBC) count
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 23(6),38,1979
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/m3/6H/22W-I
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Vascular - BP lowering not characterized in autonomic section
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 28(12),14,1963
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5 mg/m3/24H/13W-C
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Kidney, Ureter, Bladder - other changes in urine composition
Blood - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 31(2),3,1966
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 15 gm/kg/30D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 29(4),24,1964
** MUTATION DATA **
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 330 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 116,379,1983
*** REVIEWS ***
ACGIH TLV-STEL 483 mg/m3 (100 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 242 mg/m3 (50 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD:air-CL 100 ppm (480 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,170,1971
OSHA PEL (Gen Indu):CL 100 ppm (480 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):CL 100 ppm (480 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):CL 100 ppm (480 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):CL 100 ppm (480 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 50 ppm (240 mg/m3);STEL 100 ppm (485 mg/m3) JAN 1993
OEL-BELGIUM:TWA 50 ppm (242 mg/m3);STEL 100 ppm (484 mg/m3) JAN 1993
OEL-DENMARK:TWA 50 ppm (240 mg/m3) JAN 1993
OEL-FINLAND:TWA 100 ppm (480 mg/m3);STEL 150 ppm (720 mg/m3) JAN 1993
OEL-FRANCE:TWA 59 ppm (240 mg/m3) JAN 1993
OEL-GERMANY:TWA 100 ppm (480 mg/m3) JAN 1993
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 50 ppm (240 mg/m3) JAN 1993
OEL-THAILAND:TWA 100 ppm (480 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 100 ppm (480 mg/m3);STEL 100 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO alpha-METHYLSTYRENE-air:10H TWA 50 ppm;STEL 100 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1533
No. of Facilities: 1933 (estimated)
No. of Industries: 20
No. of Occupations: 32
No. of Employees: 24824 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1533
No. of Facilities: 354 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 3214 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9275
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501
*** END OF RECORD ***