*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WO9270000
CHEMICAL NAME           : Sulfanilamide, N(sup 1)-(2,6-dimethyl-4-pyrimidinyl)-
CAS REGISTRY NUMBER     : 515-64-0
BEILSTEIN REFERENCE NO. : 0261305
REFERENCE               : 5-25-10-00216 (Beilstein Handbook Reference)
LAST UPDATED            : 199707
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C12-H14-N4-O2-S
MOLECULAR WEIGHT        : 278.36
WISWESSER LINE NOTATION : T6N CNJ B1 D1 FMSWR DZ
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 6-(p-Aminobenzenesulfonamido)-2,4-dimethylpyrimidine
   * 6-(4-Aminobenzenesulfonamido)-2,4-dimethylpyrimidine
   * 6-(p-Aminobenzenesulfonyl)amino-2,4-dimethylpyrimidine
   * (p-Aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidin
   * 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide
   * Aristamid
   * Aristogyn
   * Benzenesulfonamide, 4-amino-N-(2,6-dimethyl-4-pyrimidinyl)-
   * N(sup 1)-(2,6-Dimethyl-4-pyrimidinyl)sulfanilamide
   * 2,4-Dimethyl-6-sulfanilamidopyrimidine
   * 2,6-Dimethyl-4-sulfanilamidopyrimidine
   * Domian
   * Elcosine
   * Elkosil
   * Elkosin
   * Elkosine
   * Erycon
   * Mefenal
   * 4-Sulfa-2,6-dimethylpyrimidine
   * Sulfadimetine
   * Sulfaisodimerazine
   * Sulfaisodimidine
   * Sulfamethin
   * 4-Sulfanilamido-2,6-dimethylpyrimidine
   * 6-Sulfanilamido-2,4-dimethylpyrimidine
   * Sulfasomidine
   * Sulfisomidin
   * Sulfisomidine
   * Sulphasomidine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 94,338,1953
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6 gm/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 13,7,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2500 mg/kg
SEX/DURATION            : female 8-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   AKGIAO Akushcherstvo i Ginekologiya (Moscow).  (V/O Mezhdunarodnaya Kniga,
   113095 Moscow, USSR) No.1-    1936-  Volume(issue)/page/year: 43(12),10,1967
 
                            *** END OF RECORD ***