*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : WP0700000
CHEMICAL NAME : Sulfanilamide, N'-(5-methyl-3-isoxazolyl)-
CAS REGISTRY NUMBER : 723-46-6
BEILSTEIN REFERENCE NO. : 0226453
REFERENCE : 4-27-00-04685 (Beilstein Handbook Reference)
LAST UPDATED : 199706
DATA ITEMS CITED : 20
MOLECULAR FORMULA : C10-H11-N3-O3-S
MOLECULAR WEIGHT : 253.30
WISWESSER LINE NOTATION : T5NOJ C1 EMSWR DZ
COMPOUND DESCRIPTOR : Tumorigen
Drug
Human
SYNONYMS/TRADE NAMES :
* A047
* 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
* 3-(para-Aminophenylsulphonamido)-5-methylisoxazole
* Azo-gantanol
* Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-
* Gantanol
* N'-(5-Methyl-3-isoxazole)sulfanilamide
* N'-(5-Methyl-3-isoxazolyl)sulfanilamide
* 5-Methyl-3-sulfanilamidoisoxazole
* 5-Methyl-3-sulfanylamidoisoxazole
* N'-(5-Methylisoxazol-3-yl)sulphanilamide
* N(sup 1)-(5-Methyl-3-isoxazolyl)sulphanilamide
* MS 53
* 5-Methyl-3-sulphanil-amidoisoxazole
* Metoxal
* Radonil
* Ro 4-2130
* Sinomin
* Sulfamethoxazol
* Sulfamethoxazole
* 3-Sulfanilamido-5-methylisoxazole
* Sulfisomezole
* Sulphamethoxazol
* Sulphamethoxazole
* Sulpha-methoxizole
* Sulphamethylisoxazole
* 3-Sulphanilamido-5-methylisoxazole
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 160 mg/kg/10D-I
TOXIC EFFECTS :
Endocrine - hypoglycemia
REFERENCE :
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago,
IL 60610) V.1- 1908- Volume(issue)/page/year: 143,827,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
18,185,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2690 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
21,175,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
21,175,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher
information, see CHTHBK. Volume(issue)/page/year: 8,63,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2300 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
21,175,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
21,175,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1460 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IRAK "Modern Pharmaceuticals of Japan, V," Tokyo, Japan Pharmaceutical,
Medical and Dental Supply Exporters' Assoc., 1975 Volume(issue)/page/year:
-,105,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher
information, see CHTHBK. Volume(issue)/page/year: 6,273,1963
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
12ZWAM "Experimental Chemotherapy, Volume II," Schnitzer, R.J., and F.
Hawking, eds. Academic Press, New York, 1964 Volume(issue)/page/year:
2,249,1964
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 67500 mg/kg/30D-I
TOXIC EFFECTS :
Endocrine - changes in thyroid weight
Blood - normocytic anemia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year:
21,175,1973
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 21 gm/kg/60W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Endocrine - thyroid tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
24,351,1973
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 24,285,1980
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 24,285,1980
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,348,1987
TOXICOLOGY REVIEW
HFHBAG Hartford Hospital Bulletin. (Hartford Hospital, 80 Seymour St.,
Hartford, CT 06115) V.1- 1938/39- Volume(issue)/page/year: 29,364,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81525
No. of Facilities: 58 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 230 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2070
No. of Facilities: 88 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 4250 (estimated)
No. of Female Employees: 4016 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81525
No. of Facilities: 853 (estimated)
No. of Industries: 3
No. of Occupations: 9
No. of Employees: 17028 (estimated)
No. of Female Employees: 11965 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***