*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : WR3450000 CHEMICAL NAME : Sulfone, bis(p-chlorophenyl) CAS REGISTRY NUMBER : 80-07-9 BEILSTEIN REFERENCE NO. : 2052955 REFERENCE : 4-06-00-01587 (Beilstein Handbook Reference) LAST UPDATED : 199712 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C12-H8-Cl2-O2-S MOLECULAR WEIGHT : 287.16 WISWESSER LINE NOTATION : GR DSWR DG COMPOUND DESCRIPTOR : Tumorigen SYNONYMS/TRADE NAMES : * Benzene, 1,1'-sulfonylbis(4-chloro- * Bis(p-chlorophenyl) sulfone * Bis(4-chlorophenyl) sulfone * p-Chlorophenyl sulfone * 4-Chlorophenyl sulfone * p,p'-Dichlorodiphenyl sulfone * 4,4'-Dichlorodiphenyl sulfone * Di-p-chlorophenyl sulfone * 1,1'-Sulfonylbis(4-chlorobenzene) *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7500 mg/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533718 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 24 gm/kg TOXIC EFFECTS : Behavioral - tremor REFERENCE : HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 29,1317,1946 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 364 mg/kg/26W-I TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS Liver - liver function tests impaired REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(2),84,1982 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 ppm JAN 1993 *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 NTP Carcinogenesis studies; on test (two year studies), October 1997 NTP Carcinogenesis studies; test completed (peer review), October 1997 *** END OF RECORD ***