*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WR3450000
CHEMICAL NAME           : Sulfone, bis(p-chlorophenyl)
CAS REGISTRY NUMBER     : 80-07-9
BEILSTEIN REFERENCE NO. : 2052955
REFERENCE               : 4-06-00-01587 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C12-H8-Cl2-O2-S
MOLECULAR WEIGHT        : 287.16
WISWESSER LINE NOTATION : GR DSWR DG
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * Benzene, 1,1'-sulfonylbis(4-chloro-
   * Bis(p-chlorophenyl) sulfone
   * Bis(4-chlorophenyl) sulfone
   * p-Chlorophenyl sulfone
   * 4-Chlorophenyl sulfone
   * p,p'-Dichlorodiphenyl sulfone
   * 4,4'-Dichlorodiphenyl sulfone
   * Di-p-chlorophenyl sulfone
   * 1,1'-Sulfonylbis(4-chlorobenzene)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7500 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0533718
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 24 gm/kg
TOXIC EFFECTS :
   Behavioral - tremor
REFERENCE :
   HCACAV Helvetica Chimica Acta.  (Verlag Helvetica Chimica Acta, Postfach,
   CH-4002 Basel, Switzerland) V.1-    1918-  Volume(issue)/page/year:
   29,1317,1946
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 364 mg/kg/26W-I
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Liver - liver function tests impaired
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 47(2),84,1982

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-RUSSIA:STEL 10 ppm JAN 1993

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NTP Carcinogenesis studies; on test (two year studies), October 1997
   
   NTP Carcinogenesis studies; test completed (peer review), October 1997

 
                            *** END OF RECORD ***