*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WS3560000
CHEMICAL NAME           : Sulfoximine, S-(3-amino-3-carboxypropyl)-S-methyl-,
                          DL-
CAS REGISTRY NUMBER     : 1982-67-8
OTHER CAS REGISTRY NOS. : 407-40-9
LAST UPDATED            : 199206
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C5-H12-N2-O3-S
MOLECULAR WEIGHT        : 180.25
WISWESSER LINE NOTATION : QVYZ2S1&UM -DL
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 2-Amino-4-(S-methylsulfonimidoyl)butanoic acid
   * Butanoic acid, 2-amino-4-(S-methylsulfonimidoyl)-
   * Methionine sulfoximine
   * Methionine-DL-sulfoximine, DL-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 218 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 94,12,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#03652
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 350 mg/kg
SEX/DURATION            : female 9-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   ASMUAA Acta Scholae Medicinalis Universitatis in Kioto.  (Kyoto, Japan)
   V.27-40, 1947-70. Discontinued.  Volume(issue)/page/year: 38,193,1962
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3500 mg/kg
SEX/DURATION            : female 9-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ASMUAA Acta Scholae Medicinalis Universitatis in Kioto.  (Kyoto, Japan)
   V.27-40, 1947-70. Discontinued.  Volume(issue)/page/year: 38,193,1962
 
                            *** END OF RECORD ***