*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WU7682000
CHEMICAL NAME           : Sydnone imine, 3-(alpha-methylphenethyl)-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 3441-64-3
OTHER CAS REGISTRY NOS. : 26814-89-1
LAST UPDATED            : 199403
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C11-H13-N3-O.Cl-H
MOLECULAR WEIGHT        : 239.73
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 3-(alpha-Methylphenethyl)sydnone imine monohydrochloride
   * 3-(beta-Phenylisopropyl)-sidnonimine hydrochloride
   * Sidnofen
   * Sydnone imine, 3-(1-methyl-2-phenylethyl)-, monohydrochloride
   * Sydnophene
   * Sydnophen hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 35,169,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 123 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 35,169,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 51 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 35,169,1972
 
                            *** END OF RECORD ***