*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : WZ1225000
CHEMICAL NAME           : Terephthalic acid, dimethyl ester
CAS REGISTRY NUMBER     : 120-61-6
LAST UPDATED            : 199710
DATA ITEMS CITED        : 17
MOLECULAR FORMULA       : C10-H10-O4
MOLECULAR WEIGHT        : 194.20
WISWESSER LINE NOTATION : 1OVR DVO1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * 1,4-Benzenedicarboxylic acid, dimethyl ester
   * Dimethyl 1,4-benzenedicarboxylate
   * Dimethylester kyseliny tereftalove
   * Dimethyl p-phthalate
   * Di-Me terephthalate
   * Dimethyl terephthalate
   * DMT
   * Methyl 4-carbomethoxybenzoate
   * Methyl p-(methoxycarbonyl)benzoate
   * NCI-C50055
   * Terephthalic acid methyl ester
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/24H
REACTION SEVERITY       : Mild
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,386,1986
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New
   York, John Wiley & Sons, Inc., 1958-63  Volume(issue)/page/year: 2,1906,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3900 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   34,455,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New
   York, John Wiley & Sons, Inc., 1958-63  Volume(issue)/page/year: 2,1906,1963
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 57600 mg/kg/14W-C
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   34,455,1973
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 mg/m3/2H/22W-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Vascular - BP lowering not characterized in autonomic section
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 5,107,1963
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 umol/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 204,703,1988

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   BPCT** Progress Report from the Environmental Protection Agency to NIOSH on
   Benzenepolycarboxylates, 1974  Volume(issue)/page/year: -,183,1974

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83502
       No. of Facilities: 58 (estimated)
       No. of Industries: 5
       No. of Occupations: 7
       No. of Employees: 993 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83502
       No. of Facilities: 104 (estimated)
       No. of Industries: 3
       No. of Occupations: 3
       No. of Employees: 2467 (estimated)
       No. of Female Employees: 204 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Cell
   transform.-SA7/SHE
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   On EPA IRIS database
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NCI Carcinogenesis Bioassay (feed);equivocal evidence:mouse
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-121,79

   NCI Carcinogenesis Bioassay (feed);no evidence:rat
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-121,79

 
                            *** END OF RECORD ***