*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XF0700000
CHEMICAL NAME           : 2,2'-(2,5,8,11-Tetraoxa-1,12-dodecane diyl)bisoxirane
CAS REGISTRY NUMBER     : 1954-28-5
BEILSTEIN REFERENCE NO. : 4311213
REFERENCE               : 5-17-03-00020 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C12-H22-O6
MOLECULAR WEIGHT        : 262.34
WISWESSER LINE NOTATION : T3OTJ B1O2O2O2O1- BT3OTJ
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Mutagen
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Ayerst 62013
   * 1,2-Bis(2-(2,3-epoxypropoxy)ethoxy)ethane
   * 1,2:15,16-Diepoxy-4,7,10,13-tetraoxahexadecane
   * Epodyl
   * Ethoglucid
   * Ethoglucide
   * Etoglucid
   * Etoglucide
   * ICI-32865
   * Oxirane, 2,2'-(2,5,8,11-tetraoxadodecane-1,12-diyl)bis-
   * 2,2'-(2,5,8,11-Tetraoxadodecane-1,12-diyl)bisoxirane
   * 4,7,10,13-Tetraoxahexadecane, 1,2:15,16-diepoxy-
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Open irritation test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 10 mg/24H
REACTION SEVERITY       : Mild
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   23,95,1962
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 11,209,1976
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3800 mg/kg/4W
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   36,915,1966
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 300 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 111,99,1983

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Limited Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 11,209,1976

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 11,209,1976

   IARC Cancer Review:Group 3
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

 
                            *** END OF RECORD ***