*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CD2996200
CHEMICAL NAME           : Antipyrine,
                          4-(4-(3-methyl-2-phenylmorpholino)methyl)-,
                          hydrochloride
CAS REGISTRY NUMBER     : 50321-35-2
LAST UPDATED            : 198703
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C23-H27-N3-O2.Cl-H
MOLECULAR WEIGHT        : 413.99
WISWESSER LINE NOTATION : T6N DOTJ B1 CR& A1- DT5NNVJ A1 BR& E1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-Phenyl-2,3-dimethyl-4-(phenyl-methyl-morpholino)methylpyrazolon  
   hydrochlorid
   * 4-(4-(2-Phenyl-3-methylmorpholino)methyl)antipyrine hydrochloride
   * R 445 hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 260 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 49,298,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 115 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 8,421,1958
 
                            *** END OF RECORD ***