*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CE1025000
CHEMICAL NAME           : 6a-alpha-Aporphin-1-ol, 2,11-dimethoxy-,
                          hydrochloride
CAS REGISTRY NUMBER     : 25650-97-9
LAST UPDATED            : 199712
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H21-N-O3.Cl-H
MOLECULAR WEIGHT        : 347.87
SYNONYMS/TRADE NAMES :
   * 4H-Dibenzo(de,g)quinolin-1-ol,  
   5,6,6a,7-tetrahydro-2,11-dimethoxy-6-methyl-, HCl, (S)-
   * 2,11-Dimethoxy-6a-alpha-aporphin-1-ol hydrochloride
   * Isothebaine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 26 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AUPMAF Acta Universitatis Palackianae Olomucensis, Facultatis Medicae.
   (Statni Pedagogicke Nakladatelstvi, Ostrovni 30, 1 Nove Mesto, 113 01 Prague
   1, Czechoslovakia)  V.24-    1961-  Volume(issue)/page/year: 66,169,1973
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg/40D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in bladder weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   AUPMAF Acta Universitatis Palackianae Olomucensis, Facultatis Medicae.
   (Statni Pedagogicke Nakladatelstvi, Ostrovni 30, 1 Nove Mesto, 113 01 Prague
   1, Czechoslovakia)  V.24-    1961-  Volume(issue)/page/year: 66,169,1973
 
                            *** END OF RECORD ***