*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CE1050000
CHEMICAL NAME           : 6a-alpha-Aporphin-11-ol,
                          10-methoxy-1,2-(methylenedioxy)-
CAS REGISTRY NUMBER     : 298-45-3
LAST UPDATED            : 199803
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C19-H19-N-O4
MOLECULAR WEIGHT        : 325.39
WISWESSER LINE NOTATION : T D56 J666 1A T EO GO RN FH&&&TTJ KQ LO1 R1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Bulbocapnine
   * d-Bulbocapnine
   * (S)-(+)-Bulbocapnine
   * Bulbokaprin
   * 4-Hydroxy-3-methoxy-5,6-methylenedioxy-aporphin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 145 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
   spasmolytic)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 155,69,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 195 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 56,85,1936
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 79 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#12068
 
                            *** END OF RECORD ***