*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : CE1057900 CHEMICAL NAME : 6a-alpha-Aporphin-9-ol, 1,2,10-trimethoxy- CAS REGISTRY NUMBER : 2169-44-0 LAST UPDATED : 198208 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C20-H23-N-O4 MOLECULAR WEIGHT : 341.44 WISWESSER LINE NOTATION : T C6666 1A Q KN&TT&J EO1 FQ K1 PO1 QO1 COMPOUND DESCRIPTOR : Drug Natural Product SYNONYMS/TRADE NAMES : * 4H-Dibenzo(de,g)quinolin-9-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, (S)- * Lauroscholtzine * N-Methyllaurotetanine * (+)-N-Methyllaurotetanine * Rogersine * 1,2,10-Trimethoxy-6a-alpha-aporphin-9-ol *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 450 mg/kg TOXIC EFFECTS : Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 170 mg/kg TOXIC EFFECTS : Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980 *** END OF RECORD ***