*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CE1057950
CHEMICAL NAME           : 6a-alpha-Aporphin-11-ol, 1,2,10-trimethoxy-
CAS REGISTRY NUMBER     : 475-67-2
BEILSTEIN REFERENCE NO. : 0094792
REFERENCE               : 5-21-06-00132 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C20-H23-N-O4
MOLECULAR WEIGHT        : 341.44
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Artabotrin
   * Artabotrine
   * 4H-Dibenzo(de,g)quinolin-11-ol,  
   5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, (S)-
   * Isocorydine
   * (+)-Isocorydine
   * d-Isocorydine
   * L-(+)-Isocorydine
   * S-(+)-Isocorydine
   * Luteanin
   * Luteanine
   * Luteanine (aporphine)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10900 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AUPMAF Acta Universitatis Palackianae Olomucensis, Facultatis Medicae.
   (Statni Pedagogicke Nakladatelstvi, Ostrovni 30, 1 Nove Mesto, 113 01 Prague
   1, Czechoslovakia)  V.24-    1961-  Volume(issue)/page/year: 61,213,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 104 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTYAD8 Zhongcaoyao.  Chinese Traditional and Herbal Medicine.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11-
      1980-  Volume(issue)/page/year: 12,402,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 52 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 31,44,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTYAD8 Zhongcaoyao.  Chinese Traditional and Herbal Medicine.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11-
      1980-  Volume(issue)/page/year: 12,402,1981
 
                            *** END OF RECORD ***