*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CE5945000
CHEMICAL NAME           : Arabic gum
CAS REGISTRY NUMBER     : 9000-01-5
LAST UPDATED            : 199701
DATA ITEMS CITED        : 12
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Reproductive Effector
                          Natural Product
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Acacia
   * Acacia dealbata gum
   * Acacia gum
   * Acacia senegal
   * Acacia syrup
   * Australian gum
   * Gum acacia
   * Gum arabic
   * Gum ovaline
   * Gum senegal
   * Indian gum
   * NCI-C50748
   * Senegal gum
   * Starsol No. 1
   * Wattle gum
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 36 mg/5H
REACTION SEVERITY       : Severe
REFERENCE :
   AROPAW Archives of Ophthalmology (Chicago).  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610)  New series: V.1-44(3), 1929-50; V.64-    1960-
   Volume(issue)/page/year: 78,384,1967
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >16 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FDRLI* Food & Drug Research Laboratories, Inc., Papers.  (P.O. Box 107, Rt.
   17C, Waverly, NY 14892-0107)  Volume(issue)/page/year: 124,-,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >16 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FDRLI* Food & Drug Research Laboratories, Inc., Papers.  (P.O. Box 107, Rt.
   17C, Waverly, NY 14892-0107)  Volume(issue)/page/year: 124,-,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 8 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FDRLI* Food & Drug Research Laboratories, Inc., Papers.  (P.O. Box 107, Rt.
   17C, Waverly, NY 14892-0107)  Volume(issue)/page/year: 124,-,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : >18 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FDRLI* Food & Drug Research Laboratories, Inc., Papers.  (P.O. Box 107, Rt.
   17C, Waverly, NY 14892-0107)  Volume(issue)/page/year: 124,-,1976
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1260 gm/kg/13W-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Kidney, Ureter, Bladder - changes in bladder weight
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 14,221,1982
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 350 gm/kg
SEX/DURATION            : male 10 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 8,357,1986
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 54600 mg/kg/10W (Continuous)
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 8,357,1986

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80049
       No. of Facilities: 22717 (estimated)
       No. of Industries: 164
       No. of Occupations: 82
       No. of Employees: 145958 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80049
       No. of Facilities: 15564 (estimated)
       No. of Industries: 78
       No. of Occupations: 71
       No. of Employees: 151589 (estimated)
       No. of Female Employees: 24766 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   NTP Carcinogenesis Bioassay (feed);no evidence:mouse,rat
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-227,82

 
                            *** END OF RECORD ***