*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CF1995500
CHEMICAL NAME           : Arginine, monohydrochloride, L-
CAS REGISTRY NUMBER     : 1119-34-2
LAST UPDATED            : 199701
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C6-H14-N4-O2.Cl-H
MOLECULAR WEIGHT        : 210.70
WISWESSER LINE NOTATION : MUYZM3YZVQ &GH
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Argamine
   * Arginine hydrochloride
   * Arginine, hydrochloride, L-
   * L-Arginine hydrochloride
   * Arginine monohydrochloride
   * L-Arginine, monohydrochloride
   * Argivene
   * Detoxargin
   * Levargin
   * Minophagen A
   * R-Gene
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 12 gm/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 62,49,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3793 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ABBIA4 Archives of Biochemistry and Biophysics.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.31-    1951-  Volume(issue)/page/year:
   58,253,1955
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 90 mg/kg
SEX/DURATION            : female 1-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   AJEBAK Australian Journal of Experimental Biology and Medical Science.
   (Adelaide, S.A., Australia) V.1-64, 1924-86.  Volume(issue)/page/year:
   51,553,1973

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 81859
       No. of Facilities: 86 (estimated)
       No. of Industries: 2
       No. of Occupations: 3
       No. of Employees: 857 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 81859
       No. of Facilities: 585 (estimated)
       No. of Industries: 3
       No. of Occupations: 13
       No. of Employees: 5477 (estimated)
       No. of Female Employees: 2954 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***