*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CF7875000
CHEMICAL NAME           : Arsanilic acid
CAS REGISTRY NUMBER     : 98-50-0
BEILSTEIN REFERENCE NO. : 1102334
REFERENCE               : 4-16-00-01190 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 35
MOLECULAR FORMULA       : C6-H8-As-N-O3
MOLECULAR WEIGHT        : 217.07
WISWESSER LINE NOTATION : ZR D-AS-QQO
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * Acide p-arsanilique
   * p-Aminobenzenearsonic acid
   * 4-Aminobenzenearsonic acid
   * Aminophenylarsine acid
   * p-Aminophenylarsine acid
   * p-Aminophenylarsonic acid
   * (4-Aminophenyl)arsonic acid
   * p-Anilinearsonic acid
   * p-Arsanilic acid
   * 4-Arsanilic acid
   * Arsanilic acid-100
   * Arsonic acid, (4-aminophenyl)-
   * AS-101
   * Atoxylic acid
   * Benzenearsonic acid, p-amino-
   * Kyselina arsanilova
   * Pro-Gen
   * Progen 90
   * Pro-Gen 227 premix
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 80,393,1944
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JCHAAE Journal of Chemotherapy and Advanced Therapeutics.  (Philadephia, PA)
    V.3,1926; V.11(2)-15, 1934-39.  Volume(issue)/page/year: 11,34,1934
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 248 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 37,483,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#06774
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 23,107,1924
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 243 mg/kg/30D-I
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Liver - hepatitis (hepatocellular necrosis), zonal
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   LBASAE Laboratory Animal Science.  (American Assoc. for Laboratory Animal
   Science, 210 N. Hammes Ave., Suite 205, Joliet, IL 60435)  V.21-    1971-
   Volume(issue)/page/year: 30,234,1980

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Inadequate Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 23,39,1980

   TOXICOLOGY REVIEW
   85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
   Washington, DC, National Academy of Sciences, 1972-77
   Volume(issue)/page/year: As,-,1977

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 0.5 mg(As)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year: 3,16,1971

   OSHA PEL (Gen Indu):8H TWA 0.5 mg(As)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Construc):8H TWA 0.5 mg(As)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Shipyard):8H TWA 0.5 mg(As)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

   OSHA PEL (Fed Cont):8H TWA 0.5 mg(As)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   41,50-204.50,1994

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-ARAB Republic of Egypt:TWA 0.2 mg(As)/m3 JAN 1993
   
   OEL-AUSTRALIA:TWA 0.05 mg(As)/m3;Carcinogen JAN 1993
   
   OEL-BELGIUM:TWA 0.2 mg(As)/m3 JAN 1993
   
   OEL-DENMARK:TWA 0.05 mg(As)/m3 JAN 1993
   
   OEL-FINLAND;Carcinogen JAN 1993
   
   OEL-FRANCE:TWA 0.2 mg(As)/m3 JAN 1993
   
   OEL-HUNGARY:STEL 0.5 mg(As)/m3;Carcinogen JAN 1993
   
   OEL-INDIA:TWA 0.2 mg(As)/m3 JAN 1993
   
   OEL-THE PHILIPPINES:TWA 0.5 mg(As)/m3 JAN 1993
   
   OEL-POLAND:TWA 0.3 mg(As)/m3 JAN 1993
   
   OEL-SWEDEN:TWA 0.03 mg(As)/m3;Carcinogen JAN 1993
   
   OEL-SWITZERLAND:TWA 0.1 mg(As)/m3;Carcinogen JAN 1993
   
   OEL-THAILAND:TWA 0.5 mg(As)/m3 JAN 1993
   
   OEL-TURKEY:TWA 0.5 mg(As)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.2 mg(As)/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 84586
       No. of Facilities: 92 (estimated)
       No. of Industries: 2
       No. of Occupations: 11
       No. of Employees: 2552 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 84586
       No. of Facilities: 175 (estimated)
       No. of Industries: 2
       No. of Occupations: 6
       No. of Employees: 1853 (estimated)
       No. of Female Employees: 1480 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   NIOSH Analytical Method, 1994: Arsenic, organo-, 5022

 
                            *** END OF RECORD ***