*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : CG3325000
CHEMICAL NAME : Arsenic trioxide
CAS REGISTRY NUMBER : 1327-53-3
LAST UPDATED : 199712
DATA ITEMS CITED : 81
MOLECULAR FORMULA : As2-O3
MOLECULAR WEIGHT : 197.84
WISWESSER LINE NOTATION : AS2 O3
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Acide arsenieux
* Anhydride arsenieux
* Arsenic blanc
* Arsenic oxide
* Arsenic(III) oxide
* Arsenic sesquioxide
* Arsenic trioxide
* Arsenicum album
* Arsenigen saure
* Arsenious acid
* Arsenious oxide
* Arsenious trioxide
* Arsenite
* Arsenolite
* Arsenous acid
* Arsenous acid anhydride
* Arsenous anhydride
* Arsenous oxide
* Arsenous oxide anhydride
* Arsentrioxide
* Arsodent
* Claudelite
* Claudetite
* Crude arsenic
* Diarsenic trioxide
* RCRA waste number P012
* White arsenic
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 29 mg/kg
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
AEMED3 Annals of Emergency Medicine. (American College of Emergency
Physicians, 1125 Executive Circle, Irving, TX 75038)
Volume(issue)/page/year: 16,702,1987
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 286 mg/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
Liver - liver function tests impaired
Musculoskeletal - other changes
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year:
29,45,1991
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 1429 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 31,1247,1980
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 2857 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - renal function tests depressed
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year:
29,131,1991
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - man
DOSE/DURATION : 2941 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 14600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 52(1),21,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 871 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 19(3),30,1975
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8 mg/kg
TOXIC EFFECTS :
Skin and Appendages - corrosive (after topical exposure)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 19,337,1922
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIZEA2 Biochemische Zeitschrift. (Berlin, Ger.) V.1-346, 1906-67. For
publisher information, see EJBCAI. Volume(issue)/page/year: 184,360,1927
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 31500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) Beginning history not known. Volume(issue)/page/year: 14,86,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 9800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 78,392,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 10700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 78,392,1951
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1306,1935
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intradermal
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1306,1935
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20190 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) Beginning history not known. Volume(issue)/page/year: 22,284,1988
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10560 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - hypermotility, diarrhea
Blood - other changes
REFERENCE :
BIZEA2 Biochemische Zeitschrift. (Berlin, Ger.) V.1-346, 1906-67. For
publisher information, see EJBCAI. Volume(issue)/page/year: 70,144,1915
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intradermal
SPECIES OBSERVED : Bird - pigeon
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1306,1935
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intradermal
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 13 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1306,1935
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cattle
DOSE/DURATION : 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1306,1935
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 900 mg/kg/15W-I
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
5,91,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 350 ug/kg/30D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - changes in sodium
Nutritional and Gross Metabolic - changes in potassium
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 52(1),21,1987
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 31 ug/m3/24H/22W-C
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Blood - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 47(1),6,1982
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 500 ug/m3/24H/33D-C
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 47(11),74,1982
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intratracheal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 16 mg/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 19,191,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intratracheal
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 45 mg/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
Volume(issue)/page/year: 7,403,1984
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intratracheal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 75 mg/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
FKIZA4 Fukuoka Igaku Zasshi. (c/o Kyushu Daigaku Igakubu, Tatekasu,
Fukuoka-shi, Fukuoka, Japan) V.33- 1940- Volume(issue)/page/year:
71,19,1980
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intratracheal
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 40 mg/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
21,141,1983
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intratracheal
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 55450 ug/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
21,141,1983
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intratracheal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 167 mg/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160,
Japan) V.1- 1959- Volume(issue)/page/year: 20,230,1978
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intratracheal
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 39608 ug/kg/24W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JOUOD4 Journal of UOEH (University of Occupational and Environmental
Health). (Univ. of Occupational and Environmental Health, 1-1 Iseigaoka,
Yahata-nishi-ku, Kitakyushu 807, Japan) V.1- 1979-
Volume(issue)/page/year: 5(Suppl),109,1983
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intratracheal
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 55456 ug/kg/24W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JOUOD4 Journal of UOEH (University of Occupational and Environmental
Health). (Univ. of Occupational and Environmental Health, 1-1 Iseigaoka,
Yahata-nishi-ku, Kitakyushu 807, Japan) V.1- 1979-
Volume(issue)/page/year: 5(Suppl),109,1983
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intratracheal
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 30 mg/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160,
Japan) V.1- 1959- Volume(issue)/page/year: 24,523,1982
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE : 600 mg/kg
SEX/DURATION : female 30 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - Apgar score (human only)
Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St.,
Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960-
Volume(issue)/page/year: 117,328,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 224 mg/kg
SEX/DURATION : multigenerations
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
23,102,1971
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 3636 mg/kg
SEX/DURATION : female 1-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
52GUAX "Anorganische Stoffe in der Toxikologie and Kriminalistik, Symposium,
Mosbach, Fed. Rep. Ger., 1983," Heppenheim, Fed. Rep. Ger., Verlag Dr.
Dieter Helm, 1983 Volume(issue)/page/year: -,91,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 8250 ug/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - immune and
reticuloendothelial system
Reproductive - Effects on Newborn - behavioral
REFERENCE :
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) Beginning history not known. Volume(issue)/page/year: 28,20,1994
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 1650 ug/kg
SEX/DURATION : female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) Beginning history not known. Volume(issue)/page/year: 28,20,1994
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE : 28500 ug/m3/4H
SEX/DURATION : female 9-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including
somatic cell genetic material)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 5,61,1985
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE : 260 ug/m3/4H
SEX/DURATION : female 9-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 5,61,1985
** MUTATION DATA **
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 50 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 77,109,1980
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Lung
DOSE/DURATION : 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 315,11,1994
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human HeLa cell
DOSE/DURATION : 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 92,427,1982
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 1200 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 88,73,1981
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 2 ug/cm3
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068
Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 19,255,1986
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 1 mg/kg
REFERENCE :
GNKAA5 Genetika (Moscow). For English translation, see SOGEBZ. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1965-
Volume(issue)/page/year: 20,365,1984
TYPE OF TEST : DNA inhibition
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 20 mL/kg
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit
Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
Volume(issue)/page/year: 51,605,1981
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 3696 mg/kg
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 52,445,1987
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 28500 ug/m3
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
Volume(issue)/page/year: 5,61,1985
*** REVIEWS ***
IARC Cancer Review:Human Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 2,48,1973
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 23,39,1980
IARC Cancer Review:Animal Limited Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,100,1987
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 2,48,1973
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 23,39,1980
IARC Cancer Review:Group 1
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,100,1987
TOXICOLOGY REVIEW
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year: 21,132,1960
TOXICOLOGY REVIEW
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.
Discontinued. Volume(issue)/page/year: 5,51,1972
TOXICOLOGY REVIEW
PTPAD4 Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and
Metabolic Inhibitors. (Oxford, UK) V.1-2, 1976-78. For publisher
information, see PHTHDT. Volume(issue)/page/year: 1,189,1976
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: As,-,1977
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
OSHA-cancer hazard
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1018,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA;Carcinogen JAN 1993
OEL-BELGIUM;Carcinogen JAN 1993
OEL-FINLAND;Carcinogen JAN 1993
OEL-FRANCE:STEL 0.2 ppm;Carcinogen JAN 1993
OEL-GERMANY;Carcinogen JAN 1993
OEL-JAPAN:STEL 0.5 ppm;Carcinogen JAN 1993
OEL-THE PHILIPPINES:TWA 0.1 mg/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.15 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ARSENIC, INORGANIC-air:CA CL 0.002 mg(As)/m3/15M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 07570
No. of Facilities: 1284 (estimated)
No. of Industries: 6
No. of Occupations: 6
No. of Employees: 3980 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 07570
No. of Facilities: 107 (estimated)
No. of Industries: 8
No. of Occupations: 16
No. of Employees: 4657 (estimated)
No. of Female Employees: 2001 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NIOSH Analytical Method, 1994: Arsenic trioxide as As, 7901
NTP 7th Annual Report on Carcinogens, 1992 : known to be carcinogenic
NTP Carcinogenesis studies; selected, October 1997
*** END OF RECORD ***