*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CK9670000
CHEMICAL NAME           : Aurovertin
CAS REGISTRY NUMBER     : 11002-90-7
LAST UPDATED            : 198809
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C26-H34-O9
MOLECULAR WEIGHT        : 490.60
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1650 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   LLOYA2 Lloydia.  (Cincinnati, OH)  V.1-41, 1938-78.  For publisher
   information, see JNPRDF.  Volume(issue)/page/year: 27,88,1964
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - muscle contraction or spasticity
   Gastrointestinal - nausea or vomiting
REFERENCE :
   LLOYA2 Lloydia.  (Cincinnati, OH)  V.1-41, 1938-78.  For publisher
   information, see JNPRDF.  Volume(issue)/page/year: 27,88,1964
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - respiratory depression
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   LLOYA2 Lloydia.  (Cincinnati, OH)  V.1-41, 1938-78.  For publisher
   information, see JNPRDF.  Volume(issue)/page/year: 27,88,1964
 
                            *** END OF RECORD ***