*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XH4375000
CHEMICAL NAME           : Theophylline, compd. with 2-amino-2-methyl-1-propanol
                          (1:1)
CAS REGISTRY NUMBER     : 5634-34-4
LAST UPDATED            : 199107
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C7-H8-N4-O2.C4-H11-N-O
MOLECULAR WEIGHT        : 269.35
WISWESSER LINE NOTATION : ZX1Q &622 &T56 BM DN FNVMVJ F H &621
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Ambuphylline
   * Bufylline
   * Butaphyllamine
   * Buthoid
   * 1-Propanol, 2-amino-2-methyl-, compd. with theophylline (1:1)
   * 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with  
   2-amino-2-methyl-1-propanol (1:1)
   * Theophylline aminoisobutanol
   * Theophylline beta-aminoisobutanol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JLCMAK Journal of Laboratory and Clinical Medicine.  (C.V. Mosby Co., 11830
   Westline Industrial Dr., St. Louis, MO 63141)  V.1-    1915-
   Volume(issue)/page/year: 31,1337,1946
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 163 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JLCMAK Journal of Laboratory and Clinical Medicine.  (C.V. Mosby Co., 11830
   Westline Industrial Dr., St. Louis, MO 63141)  V.1-    1915-
   Volume(issue)/page/year: 31,1337,1946
 
                            *** END OF RECORD ***