*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XH4875000
CHEMICAL NAME           : Theophylline,
                          8-(benzylamino)-7-(2-hydroxy-3-(4-methyl-1-piperaziny
                          l)propyl)-, dihydrochloride
CAS REGISTRY NUMBER     : 105319-55-9
LAST UPDATED            : 199406
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C22-H31-N7-O3.2Cl-H
MOLECULAR WEIGHT        : 514.52
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   8-(Benzylamino)-7-(2-hydroxy-3-(4-methyl-1-piperazinyl)propyl)theophylli
     ne dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year: 38,85,1986
 
                            *** END OF RECORD ***