*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : XH5093050 CHEMICAL NAME : Theophylline, 8-chloro-7-(3-methyl-2-phenylmorpholino)- CAS REGISTRY NUMBER : 13931-75-4 LAST UPDATED : 197905 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C18-H20-Cl-N5-O3 MOLECULAR WEIGHT : 389.88 WISWESSER LINE NOTATION : T56 BN DN FNVNVJ B- AT6N DOTJ BR& C1& CG F1 H1 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * 8-Chloro-7-(3-methyl-2-phenylmorpholino)theophylline * Phenmetrazine 8-chlorotheophyllinate * Phenmetrazine teoclate * Phenmetrazine theoclate * Phenyl-methyl-morpholin-(dimethyl-chlor)-xanthinat * R 382 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 165 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - excitement Behavioral - changes in motor activity (specific assay) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,526,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 295 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - excitement Behavioral - changes in motor activity (specific assay) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,526,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 170 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - excitement Behavioral - changes in motor activity (specific assay) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,526,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 95 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - excitement Behavioral - changes in motor activity (specific assay) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,526,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - excitement Behavioral - changes in motor activity (specific assay) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,526,1955 *** END OF RECORD ***