*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XH5095000
CHEMICAL NAME           : Theophylline, 7-(2-diethylamino)ethyl-
CAS REGISTRY NUMBER     : 314-35-2
BEILSTEIN REFERENCE NO. : 0291098
REFERENCE               : 4-26-00-02409 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C13-H21-N5-O2
MOLECULAR WEIGHT        : 279.39
WISWESSER LINE NOTATION : T56 BN DN FNVNVJ B2N2&2 F1 H1
COMPOUND DESCRIPTOR     : Human
SYNONYMS/TRADE NAMES :
   * Camphophyline
   * Corafil
   * Diaethylaminoaethyl-theophyllin
   * Diethylaminoethyl theophylline
   * 7-(Diethylaminoethyl)theophylline
   * Etaminophylline
   * Etamiphyllin
   * Etamiphylline
   * Milliphylline
   * Millophylline
   * Parephyllin
   * 1H-Purine-2,6-dione, 7-(2-(diethylamino)ethyl)-3,7-dihydro-1,3-dimethyl-
   * Queryl
   * R-3588
   * Soluphyline
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 240 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - olfactory nerve change
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - change in rate
REFERENCE :
   HETOEA Human & Experimental Toxicology.  (Macmillan Press Ltd., Brunel Road,
   Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
   Volume(issue)/page/year: 9,201,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1237 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 116,343,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 254 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 116,343,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 182 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 4,649,1954
 
                            *** END OF RECORD ***