*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : XH5100000 CHEMICAL NAME : Theophylline, 7-(2,3-dihydroxypropyl)- CAS REGISTRY NUMBER : 479-18-5 OTHER CAS REGISTRY NOS. : 52756-53-3 BEILSTEIN REFERENCE NO. : 0284563 REFERENCE : 5-26-14-00070 (Beilstein Handbook Reference) LAST UPDATED : 199701 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C10-H14-N4-O4 MOLECULAR WEIGHT : 254.28 WISWESSER LINE NOTATION : T56 BN DN FNVNVJ B1YQ1Q F1 H1 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * AFI-Phyllin * Aristophyllin * Astmamasit * Astrophyllin * Circain * Circair * Coronal * Coronarin * Corphyllin * COR-theophylline * 7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione * Dihydroxypropyl theopylin * Dihydroxypropyl theophylline * (1,2-Dihydroxy-3-propyl)thiophyllin * 7-(2,3-Dihydroxypropyl)theophylline * 1,3-Dimethyl-7-(2,3-dihydroxypropyl)xanthine * 7-(2,3-Dioxypropyl)theophylline * Diphyllin * Diprofillin * Diprofilline * Diprophyllin * Diprophylline * Dyphylline * Glyfyllin * Glyphyllin * Glyphylline * Hidroxiteofillina * Hiphyllin * Hyphylline * Lufyllin * Neophyllin * Neophylline * Neophyllin M * Neostenovasan * Neothylline * Neotilina * Neo-vasophylline * Neufil * Neutrafil * Neutrafillina * Neutraphyllin * Neutraphylline * Neutroxantina * Propyphyllin * Protheophylline * Purifilin * 1H-Purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl * Sibephyllin * Sibephylline * Silbephylline * Solufilin * Solufyllin * Soluphyllin * Synthophylline * Tefilan * Theal * Theal ampules * Thefylan *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 35,266,1946 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1253 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 230,194,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 860 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 230,194,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1954 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,343,1956 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 195 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : STRAAA Strahlentherapie. (Urban & Schwarzenberg, Postfach 202440, D-8000 Munich 2, Fed. Rep. Ger.) V.1- 1912- Volume(issue)/page/year: 127,245,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1052 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 6,601,1956 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1080 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,288,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80405 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80405 No. of Facilities: 38 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 795 (estimated) No. of Female Employees: 486 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***